205446-80-6

Upstream product

• 205446-82-8 N-(2-Bromo-benzyl)-2-chloro-2-methylsulfanyl-N-(2-phenylsulfanyl-cyclohex-1-enyl)-acetamide 
• 205446-78-2 N-(2-Bromo-benzyl)-2-methanesulfinyl-N-(2-phenylsulfanyl-cyclohex-1-enyl)-acetamide 
• 110452-14-7 2-phenylthiocyclohexanone 
• 3959-05-5 2-bromobenzylamine 
• 205446-76-0 2-Bromo-N-(2-bromo-benzyl)-N-(2-phenylsulfanyl-cyclohex-1-enyl)-acetamide 
• 205446-77-1 N-(2-Bromo-benzyl)-2-methylsulfanyl-N-(2-phenylsulfanyl-cyclohex-1-enyl)-acetamide 

Relevant academic research and scientific papers

New entry to 1,4,5,6-tetrahydro-2h-indol-2-ones using a cationic 5-endo-trigonal cyclization onto enamides

A new method for the synthesis of 1,4,5,6-tetrahydro-2H-indol-2-ones by means of 5-endo-trigonal cyclization of α-thiocarbocations generated from sulfoxide (12) and α-chlorosulfide (17) is described. The sulfoxide (12), upon heating with TsOH, gave 14, which eliminated benzenethiol to give tetrahydroindolone (15). By contrast, the chlorosulfide (17), upon treatment with TiCl4, gave the desulfurized tetrahydroindolone (18). The mechanism for the formation of 18 is also discussed.