205490-17-1

Downstream Products

• 205490-18-2 7,9,10-trideacetylbaccatin VI 7,9-acetonide 
• 205490-20-6 7,9,10,13-tetradeacetyl-10-triethylsilylbaccatin VI 7,9-acetonide 
• 205490-19-3 7,9,10-trideacetyl-10-triethylsilylbaccatin VI 7,9-acetonide 
• 205490-29-5 7,9,10,13-tetradeacetyl-10-triethylsilylbaccatin VI 7,9-benzylidene acetal 
• 205490-28-4 7,9,10-trideacetyl-10-triethylsilylbaccatin VI 7,9-benzylidene acetal 
• 205490-21-7 10-deacetyl-9(R)-dihydro-10-triethylsilyl-2'-tert-butyldimethylsilyl-1-deoxypaclitaxel 7,9-acetonide 
• 205490-30-8 3'-N-debenzoyl-3'-N-tert-butoxycarbonyl-10-deacetyl-10-triethylsilyl-9(R)-dihydro-2'-triisopropylsilyl-1-deoxypaclitaxel 7,9-benzylidene acetal 
• 1310814-89-1 9-deacetyl-1-deoxybaccatin VI 
• 198990-70-4 1-deoxypaclitaxel 
• 1310814-84-6 7-ethanoyl-1-deoxypaclitaxel 
• 1310814-86-8 7-ethanoyl-10-chloromethanoyl-10-deacetyl-1-deoxypaclitaxel 
• 1310814-88-0 7-ethanoyl-10-cyclopropanoyl-10-deacetyl-1-deoxypaclitaxel 
• 1310814-83-5 7-ethanoyl-10-(5,6-dichloronicotinoyl)-10-deacetyl-1-deoxypaclitaxel 
• 1411664-14-6 7-ethanoyl-10-propanoyl-10-deacetyl-1-deoxypaclitaxel 

Relevant academic research and scientific papers

Synthesis and crystal structure of 7,9-dideacetyl-1-deoxybaccatinVI

7,9-dideacetyl-1-deoxybaccatinVI was synthesized from 1-deoxybaccatinVI and its crystal structure was determined by X-ray crystallographic techniques. The compound (C33H42O11·2CH4O) crystallizes into monoclinic

Semi-synthesis of 1-deoxypaclitaxel and its analogues from 1-deoxybaccatin VI

Despite numerous synthetic efforts and extensive SAR studies on paclitaxel analogs, little work has been devoted to derive SAR of the C-1 hydroxy group. Up to now, 1-deoxypaclitaxel has only been reported to be isolated from the Chinese yew, Taxus mairei

Synthesis and biological evaluation of 1-deoxypaclitaxel analogues

The naturally occurring taxoid baccatin VI has been converted to various 1-deoxypaclitaxel derivatives by selective deacylation followed by attachment of the C-13 side chain. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with activity comparable to that of paclitaxel were discovered. It thus appears that the 1-hydroxyl group is not necessary for the activity of paclitaxel.