205490-34-2

Basic information

• Product Name: 7,9-diacetyl-9(R)-dihydro-2'-triethylsilyl-1-deoxypaclitaxel
• Synonyms: 7,9-diacetyl-9(R)-dihydro-2'-triethylsilyl-1-deoxypaclitaxel
• CAS NO: 205490-34-2
• Molecular Weight: 1038.27
• Mol File: 205490-34-2.mol

Chemical Properties

• CAS DataBase Reference: 7,9-diacetyl-9(R)-dihydro-2'-triethylsilyl-1-deoxypaclitaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 7,9-diacetyl-9(R)-dihydro-2'-triethylsilyl-1-deoxypaclitaxel(205490-34-2)
• EPA Substance Registry System: 7,9-diacetyl-9(R)-dihydro-2'-triethylsilyl-1-deoxypaclitaxel(205490-34-2)

Safety Data

• Hazardous Substances Data: 205490-34-2(Hazardous Substances Data)

Upstream product

• 149249-91-2 (3R,4S)-1-benzoyl-4-phenyl-3-(triethylsilyl)oxy-2-azetidinone 
• 148877-81-0 13-deacetylbaccatin VI 

Relevant articles and documents

Synthesis and biological evaluation of 1-deoxypaclitaxel analogues

The naturally occurring taxoid baccatin VI has been converted to various 1-deoxypaclitaxel derivatives by selective deacylation followed by attachment of the C-13 side chain. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with activity comparable to that of paclitaxel were discovered. It thus appears that the 1-hydroxyl group is not necessary for the activity of paclitaxel.