Azido-PEG6-NHS ester is a versatile chemical compound that consists of an azide (N3) and an NHS ester functional group, with a hydrophilic PEG6 spacer that enhances solubility in aqueous media. The azide group enables reactions with alkyne, BCN, and DBCO through Click Chemistry, resulting in a stable triazole linkage. The NHS ester allows for the labeling of primary amines (-NH2) present in proteins, amine-modified oligonucleotides, and other amine-containing molecules.
2055014-64-5
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Basic information
- Product Name: Azido-PEG6-NHS ester
- Synonyms: Azido-PEG6-NHS ester
- CAS NO:2055014-64-5
- Molecular Formula: C19H32N4O10
- Molecular Weight: 476.47818
- EINECS: N/A
- Product Categories: N/A
- Mol File: 2055014-64-5.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in Water, DMSO, DCM, DMF
- CAS DataBase Reference: Azido-PEG6-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: Azido-PEG6-NHS ester(2055014-64-5)
- EPA Substance Registry System: Azido-PEG6-NHS ester(2055014-64-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 2055014-64-5(Hazardous Substances Data)
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2055014-64-5 Usage
Uses
Used in Bioconjugation:Azido-PEG6-NHS ester is used as a bioconjugation agent for the covalent attachment of proteins, peptides, and other amine-containing molecules to various surfaces, nanoparticles, or other biomolecules. This is achieved through the reaction of the NHS ester with primary amines, forming stable amide bonds.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG6-NHS ester is used as a component in drug delivery systems for the targeted delivery of therapeutic agents. The PEG spacer improves the solubility and stability of drug conjugates, while the azide group allows for the incorporation of clickable functionalities through Click Chemistry, enabling the attachment of drugs, imaging agents, or other targeting moieties.
Used in Molecular Probes and Imaging:
Azido-PEG6-NHS ester is used as a molecular probe and imaging agent in biological research and diagnostics. The azide group can be used to attach fluorescent tags, spin labels, or other reporter groups to biomolecules, enabling their tracking and visualization within biological systems.
Used in Materials Science:
In the field of materials science, Azido-PEG6-NHS ester is used for the functionalization of surfaces and the creation of stimuli-responsive materials. The azide group can be used to introduce clickable functionalities onto surfaces, allowing for the subsequent attachment of various molecules through Click Chemistry. This enables the development of materials with tailored properties, such as self-healing or drug-releasing capabilities.
Used in Chemical Biology:
Azido-PEG6-NHS ester is used as a tool in chemical biology for the study of protein function, enzyme activity, and cellular processes. Azido-PEG6-NHS ester can be used to label proteins of interest, enabling their tracking, quantification, and manipulation within biological systems. Additionally, the azide group can be used to introduce photo-crosslinking or photo-cleavable functionalities, allowing for the investigation of protein-protein interactions and the elucidation of cellular pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 2055014-64-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,5,5,0,1 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.Calculate Digit Verification of CAS Registry Number 2055014-64:
(9*2)+(8*0)+(7*5)+(6*5)+(5*0)+(4*1)+(3*4)+(2*6)+(1*4)=115
115 % 10 = 5
So 2055014-64-5 is a valid CAS Registry Number.
2055014-64-5Upstream product
2055014-64-5Downstream Products
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Azido-PEG6-NHS ester
