Propargyl-PEG8-t-butyl ester is a PEG reagent with an alkyne group and a t-butyl group. The alkyne group enables the formation of triazole linkage with azide-bearing compounds or biomolecules; copper is required as a catalyst. The t-butyl group can be hydrolyzed under acidic conditions. The hydrophilicity of the molecule is improved by having 8 units of PEG.
2055014-96-3
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Basic information
- Product Name: Propargyl-PEG8-t-butyl ester
- Synonyms: Propargyl-PEG8-t-butyl ester
- CAS NO:2055014-96-3
- Molecular Formula: C24H44O10
- Molecular Weight: 492.60016
- EINECS: N/A
- Product Categories: N/A
- Mol File: 2055014-96-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 528.4±45.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.064±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in Water, DMSO, DCM, DMF
- CAS DataBase Reference: Propargyl-PEG8-t-butyl ester(CAS DataBase Reference)
- NIST Chemistry Reference: Propargyl-PEG8-t-butyl ester(2055014-96-3)
- EPA Substance Registry System: Propargyl-PEG8-t-butyl ester(2055014-96-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 2055014-96-3(Hazardous Substances Data)
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2055014-96-3 Usage
Uses
Used in Bioconjugation:Propargyl-PEG8-t-butyl ester is used as a bioconjugation agent for the covalent attachment of azide-containing biomolecules. The alkyne group allows for the formation of stable triazole linkages through copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the efficient and specific conjugation of various biomolecules.
Used in Drug Delivery Systems:
Propargyl-PEG8-t-butyl ester is used as a component in drug delivery systems for improving the solubility and bioavailability of hydrophobic drugs. The hydrophilic nature of the PEG units enhances the water solubility of the drug conjugates, while the t-butyl ester group can be hydrolyzed under acidic conditions, allowing for controlled drug release in specific environments.
Used in Polymer Science:
Propargyl-PEG8-t-butyl ester is used as a building block in the synthesis of functional polymers. The alkyne group can be used for further click chemistry reactions, enabling the creation of complex polymer structures with tailored properties for various applications, such as hydrogels, micelles, and nanoparticles.
Used in Surface Modification:
Propargyl-PEG8-t-butyl ester is used for modifying surfaces with PEGylated layers. The alkyne group can be used to attach the molecule to azide-modified surfaces, providing a hydrophilic and biocompatible coating that can reduce protein adsorption and cell adhesion, which is useful in biomedical applications such as implants and biosensors.
Check Digit Verification of cas no
The CAS Registry Mumber 2055014-96-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,5,5,0,1 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.Calculate Digit Verification of CAS Registry Number 2055014-96:
(9*2)+(8*0)+(7*5)+(6*5)+(5*0)+(4*1)+(3*4)+(2*9)+(1*6)=123
123 % 10 = 3
So 2055014-96-3 is a valid CAS Registry Number.
2055014-96-3Upstream product
2055014-96-3Downstream Products
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Propargyl-PEG8-t-butyl ester
