Mal-PEG8-NHS ester is a PEG (polyethylene glycol) linker that features a maleimide group and an NHS (N-hydroxysuccinimide) ester group. This molecule is designed to enhance the solubility of various compounds in aqueous media, thanks to its hydrophilic PEG spacer. The presence of the maleimide and NHS ester groups allows for selective and efficient conjugation with primary amines, making it a versatile tool in biochemistry and molecular biology.
2055033-05-9
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Basic information
- Product Name: Mal-PEG8-NHS ester
- Synonyms: Mal-PEG8-NHS ester
- CAS NO:2055033-05-9
- Molecular Formula: C27H42N2O14
- Molecular Weight: 618.62738
- EINECS: N/A
- Product Categories: N/A
- Mol File: 2055033-05-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 689.3±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.29±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO, DCM, DMF
- PKA: -2.34±0.20(Predicted)
- CAS DataBase Reference: Mal-PEG8-NHS ester(CAS DataBase Reference)
- NIST Chemistry Reference: Mal-PEG8-NHS ester(2055033-05-9)
- EPA Substance Registry System: Mal-PEG8-NHS ester(2055033-05-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 2055033-05-9(Hazardous Substances Data)
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2055033-05-9 Usage
Uses
Used in Biochemical Applications:Mal-PEG8-NHS ester is used as a labeling agent for primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The application reason is to facilitate the study of these molecules' structure, function, and interactions within biological systems.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Mal-PEG8-NHS ester is used as a conjugation agent for the development of PEGylated drugs. The application reason is to improve the pharmacokinetic properties, solubility, and stability of therapeutic molecules, thereby enhancing their efficacy and reducing potential side effects.
Used in Diagnostics:
Mal-PEG8-NHS ester is used as a component in the development of diagnostic tools, such as imaging agents and biosensors. The application reason is to enable the detection and monitoring of specific biological targets, contributing to the early diagnosis and treatment of various diseases.
Used in Research and Development:
In research and development, Mal-PEG8-NHS ester is used as a versatile reagent for the creation of novel bioconjugates and the study of molecular interactions. The application reason is to advance our understanding of biological processes and facilitate the discovery of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 2055033-05-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,5,5,0,3 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.Calculate Digit Verification of CAS Registry Number 2055033-05:
(9*2)+(8*0)+(7*5)+(6*5)+(5*0)+(4*3)+(3*3)+(2*0)+(1*5)=109
109 % 10 = 9
So 2055033-05-9 is a valid CAS Registry Number.
2055033-05-9Upstream product
2055033-05-9Downstream Products
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Mal-PEG8-NHS ester
