2055536-64-4

Basic information

• Product Name: (S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid
• CAS NO: 2055536-64-4
• Molecular Weight: 603.539
• Mol File: 2055536-64-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 669.1±65.0 °C(Predicted)
• Density: 1.417±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid(2055536-64-4)
• EPA Substance Registry System: (S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid(2055536-64-4)

Safety Data

• Hazardous Substances Data: 2055536-64-4(Hazardous Substances Data)

Usage

General Description

The chemical "(S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid" is a complex compound consisting of a mixture of different elements and functional groups. It contains a fluorine-substituted aromatic ring, a benzo[b][1,4]oxazine moiety, a sulfonyl group, and a propanoic acid moiety. The compound also exhibits stereochemistry with an (S)-configuration. This chemical structure suggests potential pharmaceutical or biological activity due to the presence of various functional groups and its unique molecular arrangement. Further studies and analyses are needed to determine its specific applications and properties.

Upstream product

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Relevant articles and documents

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer

Retinoic acid receptor-related orphan receptor γ (RORc, RORγ, or NR1F3) is the nuclear receptor master transcription factor that drives the function and development of IL-17-producing T helper cells (Th17), cytotoxic T cells (Tc17), and subsets of innate lymphoid cells. Activation of RORγ+T cells in the tumor microenvironment is hypothesized to render immune infiltrates more effective at countering tumor growth. To test this hypothesis, a family of benzoxazines was optimized to provide LYC-55716 (37c), a potent, selective, and orally bioavailable small-molecule RORγ agonist. LYC-55716 decreases tumor growth and enhances survival in preclinical tumor models and was nominated as a clinical development candidate for evaluation in patients with solid tumors.