20556-14-3

Usage

Uses

Used in Pharmaceutical Industry:
H-VAL-ILE-OH is used as a key component in the preparation of antihypertensive drugs. It plays a crucial role in the development of medications that help regulate blood pressure and maintain cardiovascular health. The nonpolar nature of H-VAL-ILE-OH allows it to interact with specific biological targets, making it an effective component in the formulation of antihypertensive drugs.

InChI:InChI=1/C11H22N2O3/c1-5-7(4)9(11(15)16)13-10(14)8(12)6(2)3/h6-9H,5,12H2,1-4H3,(H,13,14)(H,15,16)/t7?,8-,9-/m0/s1

Upstream product

• 41486-97-9 Z-Val-Ile-OH 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 73-32-5 L-isoleucine 
• 6306-54-3 N-phthaloyl L-valine 

Relevant academic research and scientific papers

An expedient N-terminal attachment methodology for the solid phase peptide synthesis

A general and successful N-terminal attachment methodology is described that allows the solid phase synthesis of oligopeptides from activated N-hydroxysuccinimide esters and amino acid lithium salts. The results of studies with different coupling systems for amide bond formation are presented. The oligomers were synthesized on solid support using a carbamate linker with final TFA/CH2Cl2 cleavage. This methodology was also applied for the preparation of peptide-substituted amides and esters in high purities and excellent yields.

STUDIES OF BITTER PEPTIDES FROM CASEIN HYDROLYZATE - VII. BITTERNESS OF THE RETRO-BPIa (VAL-ILE-PHE-PRO-PRO-GLY-ARG) AND ITS FRAGMENTS.

To explain the bitter taste exhibited by BPIa (Arg-Gly-Pro-Pro-Phe-Ile-Val) which was isolated from casein hydrolyzate, the authors propose the following requirement: its characteristic spatial structure: the basic moiety in the N-terminal and the hydroph