205579-90-4Relevant academic research and scientific papers
Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
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, (2008/06/13)
The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent, such as, steroids, nonsteroidal antiinflammatory compounds (NSAID), 5-lipoxygenase (5-LO) inhibitors, leukotriene B4 (LTB4) receptor antagonists, leukotriene A4 (LTA4) hydrolase inhibitors, 5-HT agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) inhibitors, H antagonists, antineoplastic agents, antiplatelet agents, decongestants, diuretics, sedating or non-sedating anti-histamines, inducible nitric oxide synthase inhibitors, opioids, analgesics, Helicobacter pylori inhibitors, proton pump inhibitors, isoprostane inhibitors, and mixtures thereof. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.
Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
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, (2008/06/13)
The present invention relates to derivatives of the formula the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.
1,2-diarylmethylene derivatives, their methods of preparation and their uses in therapeutics
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, (2008/06/13)
The present invention relates to the derivatives of formula: STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
1,2 diarylmethylene derivatives, their methods of preparation and their uses in therapeutics
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, (2008/06/13)
The present invention relates to the derivatives of formula: STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
Diarylmethylidenefuran derivatives and their uses in therapeutics
-
, (2008/06/13)
The present invention relates to the derivatives of the formula STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
