20562-62-3Relevant academic research and scientific papers
Pyrano-indoles
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, (2008/06/13)
The present invention relates as new industrial product to a derivative of pyrano-indole chosen from the group constituted by: (i) the pyrano[2,3-g]indoles of general formula: STR1 in which: X represents a group STR2 (where R is a lower alkyl group, OH, lower alkoxy, tosyloxy, NH2) or >CH--NR'R" (where R' and R", which are identical or different, each represent H or a lower alkyl); R1 represents an atom of hydrogen, a lower alkyl group, or COY1 (where Y1 is a lower alkyl group, an amino acid group CH2 CH(COOH) NH2 or an aminoalkylene group --(CH2)n --NR'R" in which n is a whole number between 1 and 4 and R' and R" are defined as hereinabove); R2 represents an atom of hydrogen, or a COY2 group (where Y2 is OH or lower alkoxy; R3 represents an atom of hydrogen, an atom of halogen, a CHO group, lower alkyl, CF3, (CH2)n NR'R" or CO--CONR'R" (where n, R' and R" are defined as hereinabove, and R4 represents an atom of hydrogen, an atom of halogen, an OH group, lower alkyl, lower alkoxy, CF3 or NR'R" (where R' and R" are defined as hereinabove); (ii) the pyrano[3,2-f]indoles of general formula: STR3 where X, R1, R2, R3 and R4 are defined as hereinabove; and (iii) their acid addition salts. The invention also relates to the process for preparing this derivative and to its application in therapeutics.
