205698-12-0

Upstream product

• 98-91-9 thiobenzoic acid 
• 205698-11-9 (7R,8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-dimethyl-silanyloxy)-7-(5-hydroxy-pentyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 205698-10-8 (7R,8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-dimethyl-silanyloxy)-10,13-dimethyl-7-pent-4-enyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 150187-34-1 17β-acetoxy-7α-(4-penten-1-yl)androst-4-en-3-one 
• 1119-51-3 bromopentene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2352-19-4 androsta-4,6-dien-17β-ol-3-one acetate 

Downstream Products

• 205698-13-1 Thiobenzoic acid S-[5-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl)-pentyl] ester 

Relevant academic research and scientific papers

Synthesis of Oxorhenium(V) Complexes Derived from 7α-Functionalized Testosterone: First Rhenium-Containing Testosterone Derivatives

In an effort to assist in the preparation of metal-containing ligands for the androgen receptor, we have synthesized the first oxorhenium(V) complexes containing a pendant testosterone moiety.The key step in the synthesis involves the copper-catalysed, α-selective 1,6-Michael addition of a 4-pentenylmagnesium bromide to 6-dehydrotestosterone 17β-acetate.The α-stereoselectivity is governed by the presence of the C-19 methyl group.The absolute configurations of the epimers were investigated by 1H-NMR studies.Further chemical transformations of the 7α-pentenyl spacer introduced the terminal thiol group, needed for complex formation.The complex formation was accomplished by the "3+1" mixed-ligand concept using two different rhenium precursors.The obtained complexes differ with respect to the central donor atom of the tridentate ligand part, namely, S and O. - Keywords: Stereoids; Rhenium; 7α-Substituted testosterone; Androgen receptor; Chelates