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205748-03-4

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205748-03-4 Usage

Description

4'-(4-NITROBENZYLOXY)ACETOPHENONE, with the molecular formula C15H13NO4, is a yellow crystalline solid that serves as a versatile chemical compound in the field of organic chemistry. It possesses a molecular weight of 267.27 g/mol and is characterized by its aromatic and carbonyl functional groups, which make it a valuable building block for various pharmaceuticals and organic compounds. Due to its reactivity and potential hazards, it is crucial to handle this compound with care and adhere to proper safety protocols.

Uses

Used in Pharmaceutical Industry:
4'-(4-NITROBENZYLOXY)ACETOPHENONE is used as a synthetic intermediate for the production of various pharmaceuticals. Its aromatic and carbonyl functional groups contribute to its versatility in the synthesis of a wide range of medicinal compounds, making it an essential component in drug development.
Used in Organic Synthesis:
In the realm of organic synthesis, 4'-(4-NITROBENZYLOXY)ACETOPHENONE is employed as a building block for the creation of diverse organic compounds. Its functional groups facilitate various chemical reactions and transformations, allowing for the synthesis of complex organic molecules.
Used as a Reagent in Research:
4'-(4-NITROBENZYLOXY)ACETOPHENONE is utilized as a reagent in scientific research, particularly in the field of organic chemistry. Its unique properties enable researchers to explore new reaction pathways and develop innovative synthetic methods.
Used as a Catalyst in Organic Reactions:
Due to its reactivity, 4'-(4-NITROBENZYLOXY)ACETOPHENONE is also used as a catalyst in certain organic reactions. It can accelerate the rate of chemical transformations, making it a valuable tool in the synthesis of specific organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 205748-03-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,7,4 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 205748-03:
(8*2)+(7*0)+(6*5)+(5*7)+(4*4)+(3*8)+(2*0)+(1*3)=124
124 % 10 = 4
So 205748-03-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO4/c1-11(17)13-4-8-15(9-5-13)20-10-12-2-6-14(7-3-12)16(18)19/h2-9H,10H2,1H3

205748-03-4 Well-known Company Product Price

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  • Alfa Aesar

  • (A16738)  4'-(4-Nitrobenzyloxy)acetophenone, 97%   

  • 205748-03-4

  • 1g

  • 132.0CNY

  • Detail
  • Alfa Aesar

  • (A16738)  4'-(4-Nitrobenzyloxy)acetophenone, 97%   

  • 205748-03-4

  • 5g

  • 440.0CNY

  • Detail
  • Alfa Aesar

  • (A16738)  4'-(4-Nitrobenzyloxy)acetophenone, 97%   

  • 205748-03-4

  • 25g

  • 1710.0CNY

  • Detail

205748-03-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[4-[(4-nitrophenyl)methoxy]phenyl]ethanone

1.2 Other means of identification

Product number -
Other names HMS547A11

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:205748-03-4 SDS

205748-03-4Downstream Products

205748-03-4Relevant articles and documents

Acetophenone derivatives: Novel and potent small molecule inhibitors of monoamine oxidase B

Wang, Zhi-Min,Li, Xue-Mei,Xu, Wei,Li, Fan,Wang, Jin,Kong, Ling-Yi,Wang, Xiao-Bing

, p. 2146 - 2157 (2015/12/11)

Two series of acetophenone derivatives have been designed, synthesized and evaluated for human monoamine oxidase A and B inhibitory activity in vitro. Most of the tested compounds acted preferentially on MAO-B with IC50 values in the nanomolar range and weak or no inhibition of MAO-A. In particular, compounds 1j (IC50 = 12.9 nM) and 2e (IC50 = 11.7 nM) were the most potent MAO-B inhibitors being 2.76- and 2.99-fold more active than selegiline. In addition, the structure-activity relationships for MAO-B inhibition indicated that substituents at C3 and C4 of the acetophenone moiety, particularly with the halogen substituted benzyloxy, were more favorable for MAO-B inhibition. Molecular docking and kinetic studies have been carried out to explain the binding modes of MAO-B with the acetophenone derivatives. Furthermore, the representative compounds 1j and 2e showed low neurotoxicity in SH-SY5Y cells. It may be concluded that the acetophenone derivatives could be used to develop promising lead compounds for treating neurodegenerative diseases.

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