205752-51-8

Basic information

• Product Name: 6-Hydroxy-hexanoic acid 4-methoxy-benzyl ester
• Synonyms: 6-Hydroxy-hexanoic acid 4-methoxy-benzyl ester
• CAS NO: 205752-51-8
• Molecular Weight: 252.31
• Mol File: 205752-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Hydroxy-hexanoic acid 4-methoxy-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy-hexanoic acid 4-methoxy-benzyl ester(205752-51-8)
• EPA Substance Registry System: 6-Hydroxy-hexanoic acid 4-methoxy-benzyl ester(205752-51-8)

Safety Data

• Hazardous Substances Data: 205752-51-8(Hazardous Substances Data)

Upstream product

• 1191-25-9 6-Hydroxyhexanoic acid 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 205752-53-0 5-(Hydroxy-methoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester 
• 205752-56-3 5-[(5-Carboxy-pentyloxy)-methoxy-phosphoryl]-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 205752-52-9 5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester 

Relevant articles and documents

Design and synthesis of haptens for application to the preparation of chiral 1,4-dihydropyridines

Lipase-catalyzed enzymatic hydrolysis of dimethyl esters of 1,4- dihydropyridines to the monoester, which is an important intermediate for the synthesis of optically active 1,4-dihydropyridines, does not proceed directly. This paper describes the design and synthesis of novel haptens having a phosphonate group containing the requisite oxyanionic character to mimic the tetrahedral intermediate of hydrolysis, and the application of these compounds for generating antibodies with catalytic ability for the enantioselective partial hydrolysis of the dicarboxylic dimethyl ester (1) of a 1,4-dihydropyridine derivative to generate the monocarboxylic acid (2).