205756-79-2

Basic information

• Product Name: 2-[2-((S)-2-Acetylamino-6-benzyloxycarbonylamino-hexanoylamino)-2-methyl-propionylamino]-2-methyl-propionic acid tert-butyl ester
• CAS NO: 205756-79-2
• Molecular Weight: 548.68
• Mol File: 205756-79-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-((S)-2-Acetylamino-6-benzyloxycarbonylamino-hexanoylamino)-2-methyl-propionylamino]-2-methyl-propionic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-((S)-2-Acetylamino-6-benzyloxycarbonylamino-hexanoylamino)-2-methyl-propionylamino]-2-methyl-propionic acid tert-butyl ester(205756-79-2)
• EPA Substance Registry System: 2-[2-((S)-2-Acetylamino-6-benzyloxycarbonylamino-hexanoylamino)-2-methyl-propionylamino]-2-methyl-propionic acid tert-butyl ester(205756-79-2)

Safety Data

• Hazardous Substances Data: 205756-79-2(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 205756-73-6 2-{2-[(S)-6-Benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoylamino]-2-methyl-propionylamino}-2-methyl-propionic acid tert-butyl ester 
• 83537-95-5 H-Aib-Aib-O(t-Bu) 
• 86060-82-4 Fmoc-Lys(Z)-OH 

Relevant articles and documents

Linear Oligopeptides. 401. In Search of a Peptide 310-Helix in Water

The terminally blocked, sequential oligopeptides of general formula Ac-n-OtBu (n=1-4) have been synthesized by segment condensation in solution and fully characterized.Using CD technique we determined the preferred solution conformation of these hydrosolube oligomers under a variety of experimental conditions.Low populations of α-helical structure are shown by the nonamer and dodecamer in water.The amount of α-helix can be increased by increasing the pH to 12, adding 2,2,2-trifluoroethanol up to 50percent, and decreasing the temperature to 3 deg C.The effect of peptide concentration on conformation is negligible.Under membrrane-mimetic conditions the two highest oligomers appear to fold largely into a 310-helix.The observation of a peptide 310-helix in water remains elusive.Only the dodecamer shows antibacterials activity, although modest.