205759-45-1Relevant academic research and scientific papers
Preparation of acetals from aldehydes and alcohols under basic conditions
Grabowski, Jakub,Granda, Jaros?aw M.,Jurczak, Janusz
supporting information, p. 3114 - 3120 (2018/05/17)
A new, simple protocol for the synthesis of acetals under basic conditions from non-enolizable aldehydes and alcohols has been reported. Such reactivity is facilitated by a sodium alkoxide along with a corresponding trifluoroacetate ester, utilizing formation of sodium trifluoroacetate as a driving force for acetal formation. The usefulness of this protocol is demonstrated by its orthogonality with various acid-sensitive protecting groups and by good compatibility with functional groups, delivering synthetically useful acetals complementarily to the synthesis under acidic conditions from aldehydes and alcohols.
Aromatic aldehydes from benzylbromides via Cobalt(I) mediated benzyl radicals in the presence of aerial oxygen: A mild oxidation reaction in neutral condition
Goswami, Shyamaprosad,Mahapatra, Ajit Kumar
, p. 1981 - 1984 (2007/10/03)
Co(PPh3)3Cl has been shown to be a novel mediator for the conversion of benzylic bromides to aromatic aldehydes under mild conditions in the presence of acnal oxygen probably via benzylic radicals. In the absence of oxygen, the carbon-carbon coupling reactions have been utilised to attend a series of functionalised benzylic dimers.
