205813-95-2

Upstream product

• 205813-90-7 4-(2-Bromo-phenylimino)-piperidine-1-carboxylic acid tert-butyl ester 
• 1066-54-2 trimethylsilylacetylene 
• 615-36-1 2-bromoaniline 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 205813-97-4 4-(2-Bromo-phenylamino)-4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof

One aspect of the present invention relates to spirocyclic compounds. Another aspect of the present invention relates to the use of the spirocyclic compounds as ligands for mammalian G-protein-coupled receptors or sigma receptors. The present invention al

Heck reaction versus free radical reaction for the synthesis of spiro[indoline-2,4′-piperidines]

Spiro[indoline-2,4′-piperidines] can be prepared from 2-bromoaniline by using a Heck reaction or a free radical reaction as the key step. The radical process produces better yields of spiro[indoline-2,4′-piperidines] than the Heck process.