205817-29-4

Upstream product

• 93250-97-6 (2R,4S)-methyl 4-benzyl-2-tert-butyl-3-formyloxazolidine-4-carboxylate 
• 205817-28-3 methyl (S)-2-benzyl-2-(tert-butoxycarbonylamino)-3-hydroxypropanoate 
• 365402-94-4 (S)-(+)-2-amino-2-hydroxymethyl-3-phenylpropionic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 205817-31-8 C₂₀H₂₉N₃O₈ 

Relevant academic research and scientific papers

α-Substituted quisqualic acid analogs: New metabotropic glutamate receptor group II selective antagonists

Syntheses of both the α-methyl and benzyl analogs of quisqualic acid are described. Testing of these compounds for their activity at excitatory amino acid receptors revealed a striking change in activity in comparison to quisqualic acid. This structural modification results in the loss of quisqualate's potent agonist action at both non-NMDA ionotropic glutamate receptors as well as at group I mGluRs, while allowing these analogs to acquire antagonist properties with relative selectivity for group II metabotropic glutamate receptors.