20585-18-6Relevant articles and documents
Concise syntheses of d-desosamine, 2-thiopyrimidinyl desosamine donors, and methyl desosaminide analogues from d-glucose
Velvadapu, Venkata,Andrade, Rodrigo B.
, p. 145 - 150 (2008)
A concise synthesis of d-desosamine has been accomplished in five steps and in 15% overall yield from methyl α-d-glucopyranoside. Desosamine was then transformed into two known 2-thiopyrimidinyl donors (Woodward and Tatsuta donors), each in two steps. Finally, analogues of methyl desosaminide at the C-3 position were prepared (3-pyrrolidino, 3-piperidino, 3-morpholino) from a common 2,3-anhydrosugar intermediate.
MACROLIDES AND METHODS OF THEIR PREPARATION AND USE
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Paragraph 00717, (2014/10/18)
Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.
Enzymatic approach to enantiomerically pure 5-alken-2,4-diols and 4-hydroxy-5-alken-2-ones: Application to the synthesis of chiral synthons
Abate, Agnese,Brenna, Elisabetta,Costantini, Alessia,Fuganti, Claudio,Gatti, Francesco G.,Malpezzi, Luciana,Serra, Stefano
, p. 5228 - 5240 (2007/10/03)
Enantiomerically pure 1,3-diols 1-3 were obtained by a chemoenzymatic approach (lipase PS from Burkholderia cepacia). These diols were converted into useful chiral synthons, which could be considered homologues of glyceraldehyde and glyceric acid acetonid
