205866-46-2

Upstream product

• 25581-41-3 D-erythronolactone acetonide 
• 51607-16-0 2,3-O-isopropylidene-D-erythrose 
• 205866-41-7 (E)-(S)-3-(2-Benzyloxy-ethyl)-5-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-pent-4-enoic acid methyl ester 
• 205866-40-6 (Z)-(S)-5-Benzyloxy-1-[(4S,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-pent-2-en-1-ol 
• 205866-43-9 (E)-(S)-5-((4S,5R)-5-Azidomethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-(2-benzyloxy-ethyl)-pent-4-enoic acid methyl ester 
• 205866-42-8 (E)-(S)-3-(2-Benzyloxy-ethyl)-5-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-4-enoic acid methyl ester 
• 205866-15-5 (S)-5-Benzyloxy-1-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-2-yn-1-ol 
• 205866-39-3 (Z)-(S)-5-Benzyloxy-1-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-2-en-1-ol 
• 205866-44-0 (S)-3-[3-((4R,5R)-5-Azidomethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-oxiranyl]-5-benzyloxy-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine

Swainsonine (1), an inhibitor of the important glycoprotein-processing enzyme Golgi α-mannosidase II, is a clinical candidate for cancer treatment. Analogs bearing substituents at C-6 and C-7 have been prepared and evaluated as inhibitors of α-mannosidase