205874-34-6Relevant articles and documents
Synthesis of certain tricyclo[5.2.1.02,6]decane derivatives of antihypertensive potential
Abdallah, Nevine A.,Maklad, Yousreya A.
, p. 23 - 46 (2007/10/03)
A series of tricyclo[5.2.1.02,6] decane derivatives 1a-d, 2,3 and 20a-c related to the antihypertensive drugs Indoramine and Guanethidine were synthesized. The target compounds were prepared through oximation of the tricyclic ketone 8 and subsequent reduction to the endo amine analogues 5, 10, 13. Reaction of the amines with various reagents depicted in Scheme1, 2, 3 lead to the required products. The desired compounds were screened for their antihypertensive activity in desoxycorticosterone acetate (DOCA) / salt-hypertensive rats by using hydralazine as reference drag. All the compounds showed antihypertensive activity where 1c and 20c were the most active in the series.
Synthesis and pharmacological activity of derivatives of exo-trimethylenenorbornane. I
Bondavalli,Lanteri,Longobardi,Schenone
, p. 945 - 951 (2007/10/07)
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