2059-91-8

Usage

General Description

The chemical 1H-Inden-1-one, 2-phenyl-3-(1-piperidinyl)-, also known as SU4312, is a synthetic compound with potential anti-cancer and anti-inflammatory properties. It is a potent and selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, which are involved in promoting the growth and spread of cancer cells and the development of new blood vessels. SU4312 has been studied for its potential use in cancer therapy, particularly in inhibiting tumor angiogenesis and metastasis. Additionally, it has shown promising results in reducing inflammation and has been investigated for its potential use in treating various inflammatory diseases. Overall, 1H-Inden-1-one, 2-phenyl-3-(1-piperidinyl)- is a compound of interest for its therapeutic potential in cancer and inflammatory conditions.

Upstream product

• 61035-31-2 2-phenyl-3-indenethiol 
• 19096-28-7 3-bromo-2-phenyl-1H-inden-1-one 
• 53215-50-2 3-piperidino-2-phenyl-1-indenethione 
• 53241-62-6 3-(N,N-dimethylamino)-2-phenylindene-1-thione 
• 76330-40-0 (3-Ethylsulfanyl-2-phenyl-inden-1-ylidene)-dimethyl-ammonium; iodide 
• 16619-12-8 2-phenyl-indan-1-one 
• 108223-33-2 C₂₇H₂₄N₂OS 
• 110-89-4 piperidine 
• 76330-45-5 3-ethylthio-2-phenyl-1-indenone 

Relevant academic research and scientific papers

α,β-UNSATURATED THIO COMPOUNDS. XX. -CYCLOADDITION OF 3-AMINO-2-ARYL-1-INDENETHIONES TO NITRILIUM BETAINES AND PHENYL AZIDE

N,N-Disubstituted 3-amino-2-aryl-1-indenethiones react with the N-oxides of aromatic nitriles or with benzonitrile phenylimine to form 5-spiroindene-substituted 1,4,2-oxathiazoles and 2-spiroindene-substituted 1,3,4-thiadiazolines.With phenyl azide only the transformation of the thiocarbonyl group into a phenylimine group occurs.In the reaction of N-unsubstituted aminoindenethione with benzonitrile N-oxide N,N-diacylation and the parallel transformation of the thione function into ketone function are observed.The reaction of 3-phenylamino-1-indenethione in the iminoenethiol form with benzonitrile N-oxide leads to the product from S-acylation and cycloaddition at the C=N bond with the formation of a 1,4,2-oxadiazoline ring.

α,β-UNSATURATED THIO COMPOUNDS. SYNTHESIS AND SOME CHEMICAL TRANSFORMATIONS OF THE THIO DERIVATIVES OF 2-ARYL-1-INDANONES AND 2-ARYL-1,3-INDANEDIONES

In the reaction of 2-aryl-1-indanones and 2-aryl-1,3-indanediones with hydrogen sulfide in the presence of hydrogen chloride 2-aryl-3-indenethiols and 3-mercapto-2-aryl-1-indenethiones respectively are formed.The latter are readily acylated, condense with

α,β-UNSATURATED THIO COMPOUNDS. XII. SYNTHESIS AND PROPERTIES OF S-ALKYL DERIVATIVES OF 3-AMINOINDENE-1-THIONES

2-Substituted 3-amino-1-indenethiones are alkylated by alkyl iodides and triethyloxonium tetrafluoroborate with the formation of the corresponding salts of the S-alkyl derivatives or their bases.Hydrothiolysis, hydrolysis, and methanolysis of the N,N-disubstituted 3-alkylthio-2-arylindene-1-immonium salts lead to the production of new or little known types of organosulfur compounds.