20600-44-6

Basic information

• Product Name: 5-CHLORO-2-BENZOTHIAZOLINONE
• Synonyms: 5-CHLORO-2-BENZOTHIAZOLINONE;5-CHLORO-2-BENZOTHIAZOLONE;5-CHLOROBENZOTHIAZOLONE;Chlorobenzothiazolinone;2(3H)-Benzothiazolone,5-chloro-(9CI);5-CHLORO-2-BENZOTHIAZOLINONE 95+%;5-Chloro-2-benzothiazolinone ,98%;5-Chlorobenzothiazol-2-ol
• CAS NO: 20600-44-6
• Molecular Formula: C₇H₄ClNOS
• Molecular Weight: 185.63
• Product Categories: BENZOTHIAZOLE
• Mol File: 20600-44-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 234.0 to 238.0 °C
• Appearance: /
• Density: 1.515g/cm³
• Refractive Index: 1.669
• PKA: 9.57±0.20(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-BENZOTHIAZOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-BENZOTHIAZOLINONE(20600-44-6)
• EPA Substance Registry System: 5-CHLORO-2-BENZOTHIAZOLINONE(20600-44-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 20600-44-6(Hazardous Substances Data)

Usage

Chemical Properties

White to gray solid

InChI:InChI=1/C7H4ClNOS/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)

Upstream product

• 81782-43-6 5-chloro-benzothiazole-2-sulfonamide 
• 29124-55-8 2-amino-4-chlorophenyl disulfide 
• 463-58-1 carbon oxide sulfide 
• 1202680-24-7 phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 103-71-9 phenyl isocyanate 
• 3507-41-3 5-Chloro-2-(methylthio)benzothiazole 
• 201230-82-2 carbon monoxide 
• 89-61-2 2,5-dichloronitrobenzene 
• 29203-75-6 5-chloro-2-(methylsulfonyl)benzothiazole 
• 5331-91-9 5-chloro-1,3-benzothiazole-2(3H)-thione 

Downstream Products

• 33354-22-2 5-chloro-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-benzothiazol-2(3H)-one 
• 1234055-97-0 5-chloro-3-[3-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl]-3H-benzothiazol-2-one 
• 100375-25-5 5-chloro-N-methyl-2-(2-nitro-phenylsulfanyl)-aniline 
• 95476-13-4 4-chloro-2-(2-dimethylamino-ethylamino)-thiophenol 
• 95476-09-8 4-chloro-2-methylamino-thiophenol 
• 102749-64-4 [2-(6-chloro-3-phenyl-benzo[1,4]thiazin-4-yl)-ethyl]-dimethyl-amine 
• 72680-46-7 2-(5-Chloro-2-oxo-benzothiazol-3-yl)-N-(3-trifluoromethyl-phenyl)-acetamide 
• 54769-25-4 2-(5-chloro-2-oxo-2,3-dihydro-1,3-benzothiazol-3-yl)acetic acid 
• 33353-25-2 1-benzyl-4-[(5-chloro-2-oxo-benzothiazol-3-yl)-acetyl]-piperazine 
• 36857-46-2 3-(4-Hydroxypiperidino)carbonylmethyl-5-chlor-2-benzothiazolinon 
• 36857-73-5 1-[(5-chloro-2-oxo-benzothiazol-3-yl)-acetyl]-4-phenyl-piperazine 
• 85750-08-9 ethyl (5-chloro-2-oxo-1,3-benzothiazol-3(2H)-yl)acetate 

Relevant articles and documents

-

-

Method for synthesizing benzothiazole-2-ketone derivative from carbonyl sulfide and disulfide as raw materials

The invention discloses a method for synthesizing a benzothiazole-2-ketone derivative from carbonyl sulfide and disulfide as raw materials. The method comprises the following steps: mixing disulfide,inorganic sulfide and an organic solvent, introducing sufficient COS to implement a reaction, and concentrating and purifying a reaction liquid, thereby obtaining the benzothiazole-2-ketone derivative. The inorganic sulfide used in the method is adopted as an activation catalyst and is low in price and easy to obtain; a catalysis system is relatively simple, and no other catalyst promoter is addedexcept reactants and inorganic sulfide; direct dehydration is implemented in the reaction process, no other dehydration agent is used, and thus the atom economy is improved; the catalysis system is good in applicability, is applicable to synthesis of fine chemicals with high additional values, and is very good in substrate applicability to each fine chemical with high additional values; reactionsare implemented at normal temperatures, normal pressure or low pressure, and thus danger coefficients can be reduced; the reaction time is short, and the efficiency can be improved.

Facile Synthesis of Benzo[ d ]azol-2(3 H)-ones Using 2-Phenoxycarbonyl-4,5-dichloropyridazin-3(2 H)-one as Green CO Source

Developing eco-friendly, stable, and easy-to-handle acyl sources is of great importance in synthetic and green chemistry. This study describes the synthesis of benzo[d]azol-2(3H)-ones such as benzo[d]thiazol-2(3H)-ones, benzo[d]oxazol-2(3H)-ones, and benzo[d]imidazol-2(3H)-ones using 2-phenoxycarbonyl-4,5-dichloropyridazin-3(2H)-one in one pot. The reaction reported is carried out under neutral or acidic conditions in the presence of zinc or sodium bicarbonate to give the corresponding heterocycles in good to excellent yields. The reaction uses a solid stable carbonyl source that is a recyclable functional-group carrier, pyridazin-3(2H)-one.