20619-96-9Relevant academic research and scientific papers
Imidodisulfamides. I. A novel class of antagonists of slow-reacting substance of anaphylaxis
El-Fehail Ali,Dandridge,Gleason,et al.
, p. 947 - 952 (2007/10/02)
A series of N',N''-bis(aryl)- and N',N''-(aralkyl)imidodisulfamides was prepared and evaluated as antagonists of slow-reacting substance of anaphylaxis (SRS-A) induced contractions of isolated guinea pig ileum. Some of these compounds, notably N',N''-bis(4-phenylbutyl)- N',N''-bis[2-(4-chlorophenyl)ethyl]-, and N',N''-bis[2-(4-bromophenyl)ethyl]imidodisulfamides (16, 22, and 26), were moderately potent and selective antagonists of SRS-A. The influence of lipophilic (π) and electronic (σ) factors on SRS-A antagonist activity appears to be of considerable importance to the derivation of potent and selective SRS-A antagonists.
