206192-37-2Relevant academic research and scientific papers
(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents
Nomura, Masahiro,Kinoshita, Susumu,Satoh, Hiroya,Maeda, Toshio,Murakami, Koji,Tsunoda, Masaki,Miyachi, Hiroyuki,Awano, Katsuya
, p. 533 - 538 (2007/10/03)
A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.
