20620-37-5

Basic information

• Product Name: 2-Butenoic acid, 2-cyano-4-(4-methoxyphenyl)-3-methyl-, ethyl ester
• CAS NO: 20620-37-5
• Molecular Formula: C15H17NO3
• Molecular Weight: 259.305
• Mol File: 20620-37-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 2-cyano-4-(4-methoxyphenyl)-3-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 2-cyano-4-(4-methoxyphenyl)-3-methyl-, ethyl ester(20620-37-5)
• EPA Substance Registry System: 2-Butenoic acid, 2-cyano-4-(4-methoxyphenyl)-3-methyl-, ethyl ester(20620-37-5)

Safety Data

• Hazardous Substances Data: 20620-37-5(Hazardous Substances Data)

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 165809-38-1 2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester 
• 403481-83-4 ethyl 3-benzyl-2-cyano-4-(4-methoxyphenyl)-3-methylbutanoate 

Relevant articles and documents

Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized. We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, 5a,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids. All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 μM at the GluR6 receptor.