206278-26-4

Basic information

• Product Name: 2-Fluoro-3-iodopyrazine
• Synonyms: 2-Fluoro-3-iodopyrazine
• CAS NO: 206278-26-4
• Molecular Formula: C₄H₂FIN₂
• Molecular Weight: 223.9749532
• Mol File: 206278-26-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Fluoro-3-iodopyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-iodopyrazine(206278-26-4)
• EPA Substance Registry System: 2-Fluoro-3-iodopyrazine(206278-26-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 206278-26-4(Hazardous Substances Data)

Usage

General Description

2-Fluoro-3-iodopyrazine is a specialized chemical compound that belongs to the class of organic compounds known as pyrazines. Pyrazines are compounds containing a pyrazine ring, which is a six-membered aromatic heterocycle that consists of two nitrogen atoms and four carbon atoms. In 2-Fluoro-3-iodopyrazine, the pyrazine ring is substituted with a fluorine atom at the 2nd position and an iodine atom at the 3rd position. The presence of these halogens contributes to certain characteristics of the compound including its reactivity, polarity, and potential biological activity. It is often utilized as an intermediate in chemical research or in the synthesis of other chemical compounds.

Upstream product

• 4949-13-7 2-fluoropyrazine 

Downstream Products

• 604786-09-6 3-(2,3-fluoro-4-(n-hexyloxy)phenyl)-2-fluoropyrazine 
• 604786-10-9 3-(2,3-fluoro-4-(n-octyloxy)phenyl)-2-fluoropyrazine 
• 421663-07-2 2-fluoro-3-phenylpyrazine 
• 421663-11-8 2-fluoro-3-(4-n-octyloxyphenyl)pyrazine 
• 1227068-41-8 3-(3-fluoropyrazin-2-yl)cyclohex-2-enone 

Relevant articles and documents

HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS

Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.

AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS

Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Functionalization by metallation of fluoropyrazine. Diazines XXI

Lithiation of fluoropyrazine followed by quenching with various electrophiles was successfully achieved and was used to synthesize new pyrazine derivatives. A further lithiation of 2-fluoro-3-substitute, pyrazines allowed access to 2,3,6-trisubstituted pyridazine derivatives. As an application, a one-pot synthesis of a quinuclidinylfluoropyrazine has been performed. When the 3-substituent bears a TMS protected alcohol, functionalization via metallation at C6 position provides tetrasubstituted pyrazines in good yield.