20629-92-9

Basic information

• Product Name: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-1,2-dihydro-5-methyl-
• CAS NO: 20629-92-9
• Molecular Formula: C10H9ClN2O
• Molecular Weight: 208.647
• Mol File: 20629-92-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-1,2-dihydro-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-1,2-dihydro-5-methyl-(20629-92-9)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-1,2-dihydro-5-methyl-(20629-92-9)

Safety Data

• Hazardous Substances Data: 20629-92-9(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 99853-56-2 2-(4’-chlorophenyl)-1,5-dimethyl-1,2-dihydro-3H-pyrazol-3-one 
• 77509-93-4 5-chloro-1-(4-chlorophenyl)-3-methyl-1H-pyrazole-4-carbaldehyde 
• 1067647-67-9 1-(4-chlorophenyl)-2,5-dihydro-α-hydroxy-3-methyl-5-oxo-α-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester 

Relevant articles and documents

Containing substituted 1, 3, 4-thiadiazole sulfide pyrazole amide and pyrazole imine derivatives and preparation method and application

The invention discloses pyrazole amide and pyrazole imine derivatives containing substituted 1, 3, 4-thiadiazole thioether as well as a preparation method and an application of the derivatives. The compounds have the structures as shown in formulae (I) and (II). The preparation method comprises the following steps: by taking substituted hydrazine as an initial raw material, carrying out closed loop, chlorine formylation, oxidation and chloro reaction to obtain pyrazole acyl chloride; carrying out a reaction on 2-amino-5-mercapto-1, 3, 4-thiadiazole and substituted benzyl chloride to obtain 2-amino-5-substituted 1, 3, 4-thiadiazole thioether; and then, carrying out a substitution reaction on 2-amino-5-substituted 1, 3, 4-thiadiazole thioether and substituted pyrazole acyl chloride to obtain the pyrazole amide compound (I) containing substituted 1, 3, 4-thiadiazole thioether; by taking substituted hydrazine as an initial raw material, carrying out closed loop and chlorine formylation to obtain pyrazole aldehyde; carrying out an additive elimination reaction on pyrazole aldehyde and 2-amino-5-mercapto-1, 3, 4-thiadiazole under a backflow condition of anhydrous ethanol to obtain 2-substituted pyrazole imidogen-5-mercapto-1, 3, 4-thiadiazole; and then carrying out a reaction on 2-substituted pyrazole imidogen-5-mercapto-1, 3, 4-thiadiazole and substituted benzyl chloride to generate the pyrazole imine compound (II) containing substituted 1, 3, 4-thiadiazole thioether. The compounds disclosed by the invention have a good inhibiting effect on tobacco mosaic virus and can be used for preparing anti-plant virus drugs.

Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists

The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.