206351-41-9

Upstream product

• 73672-02-3 pregnenolone 21-pyridinium iodide 
• 302-97-6 androst-4-en-3-one-17β-carboxylic acid 
• 85541-82-8 methyl 5-androsten-3β-ol-17β-carboxylate 
• 145-13-1 Pregnenolone 
• 393-11-3 4-nitro-3-(trifluoromethyl)benzeneamine 
• 57072-90-9 3-oxoandrost-4-ene-17β-carboxylic acid chloride 
• 2681-55-2 3-oxo-androst-4-ene-17β-carboxylic acid methyl ester 

Downstream Products

• 206351-44-2 N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide 
• 206351-43-1 N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-azaandrost-5-ene-17β-carboxamide 
• 206351-42-0 17β-[N-(3'-trifluoromethyl-4'-nitrophenyl)aminocarbonyl]-5-oxo-A-nor-3,5-secoandrostan-3-oic acid 

Relevant academic research and scientific papers

Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 μM and 300, respectively.

Synthesis of N-substituted 3-oxo-17β -carboxamide-4-aza-5α-androstanes and the tautomerism of 3-oxo-4-aza-5-androstenes

An N-aryl-3-oxo-4-aza-5α -androst-1-ene-17β carboxamide and three N-aryl or alkyl substituted 17α -hydroxy-3-oxo-4-aza-5α -androstane-17β -carboxamides were synthesized as antiandrogen candidates from 3-oxoandrost-4-ene-17β - carboxylic acid and androst-4-ene-3,17-dione respectively. The chemo- and stereoselective reduction of 3-oxo-4-aza-5-ene intermediates with formic acid and their tautomerism in a solution of chloroform and methanol were described.