206352-50-3Relevant academic research and scientific papers
Application of the Blaise reaction: Stereoselective synthesis of (4R)- tert-butyl 3-amino-4-trimethylsilyloxy-2-alkenoates from (R)-cyanohydrins
Syed, Jana,Foerster, Siegfried,Effenberger, Franz
, p. 805 - 815 (2007/10/03)
O-Trimethylsilyl protected (R)-cyanohydrins 3 react with Reformatsky reagents from tert-butyl 2-bromoesters 4 and zinc dust (Blaise reaction) to give the corresponding addition products in high yields. Workup with an aqueous solution of NH4Cl a
