206362-79-0Relevant articles and documents
3-Chloro-4-fluorothiophene-1,1-dioxide. A new synthetically useful fluorodiene
Dmowski, Wojciech,Manko, Vladimir A.,Nowak, Ireneusz
, p. 143 - 151 (1998)
Simple, three step synthesis of a new fluorine containing diene, 3-chloro-4-fluorothiophene-1,1 -dioxide (4), from commercially available 3-sulpholene (1) has been developed. The synthetic value of compound 4 as a Diels - Alder diene has been demonstrated by its reactions with various type of dienophiles: acetylenes, alkenes, furans, quinone and anthracene. The reactions proceed with high regioselectivity to give good yields of 3-fluoro-4-chloro substituted aromatics or cyclic chlorofluorodienes. In reactions with alkenes, immediate aromatisation often occurs. In some instances, when reacted with a diene, compound 4 behaves as a dienophile.
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model
Son, Woo Seung,Jeong, Kyu-Sung,Lim, Sang Min,Pae, Ae Nim
supporting information, p. 1168 - 1172 (2019/03/28)
Highly effective and safe drugs for the treatment of neuropathic pain are urgently required and it was shown that blocking T-type calcium channels can be a promising strategy for drug development for neuropathic pain. We have developed pyrrolidine-based T