20640-68-0

Usage

Uses

2-(Acetylamino)-3-(phenylthio)propanoic Acid can be used as BTEX metabolites derivation kit.

Upstream product

• 110-89-4 piperidine 
• 64-17-5 ethanol 
• 5429-56-1 N-Acetamidoacrylic acid 
• 108-98-5 thiophenol 

Downstream Products

• 88347-91-5 2-acetamido-3-phenylsulfanylpropionic acid methyl ester 
• 88347-90-4 S-phenyl-D,L-cysteine hydrochloride 
• 98996-48-6 S-phenyl-DL-cysteine S-oxide 
• 7554-99-6 S-phenyl-DL-cysteine S,S-dioxide 
• 89024-26-0 2-acetylamino-N-methyl-3(phenylthio)propionamide 
• 5437-52-5 2-(S)-amino-3-phenylsulfanylpropionic acid 

Relevant academic research and scientific papers

Development of a class-selective enzyme-linked immunosorbent assay for mercapturic acids in human urine

Epidemiological and toxicological studies often require the analysis of large numbers of samples for biological markers of exposure. The goal of this work was to develop a class-selective ELISA to detect groups of structurally closely related mercapturic acids with small nonpolar S-substituents. An assay was developed with strong recognition for mercapturates including S-benzylmercapturic acid (IC50 = 0.018 μmol/L), S-n-hexylmercapturic acid (IC50 = 0.021 μmol/L), S-phenylmercapturic acid (IC50 = 0.024 μmol/L), and S-cyclohexylmethylmercapturic acid (IC50 = 0.042 μmol/L). The same assay also showed weaker recognition for S-(1-hydroxynaphthal-2-yl)mercapturic acid and S-allylmercapturic acid (IC50 = 1.1 and 1.7 μmol/L, respectively). Subtle modifications to the hapten linker structure of the coating antigen proved to have a strong impact on the selectivity and the specificity of the assay. A slightly modified assay showed high recognition for S-benzylmercapturic acid (IC50 = 0.018 μmol/L) and weaker recognition for seven other mercapturic acids (IC50 = 0.021-10 μmol/L). Strong positive assay responses were detected in 12 urine samples obtained from persons with no known occupational exposure to exogenous electrophilic xenobiotics. Solid phase extraction and cross-reactivity indicated that the presumptive immunoreactive materials were similar in size and polarity to S-benzylmercapturic acid. The assay was more selective to mercapturic acids than the spectrophotometric thioether assay.

Formation of β-lactams from 3-phenylthiopropionamide derivatives. A possible model for penicillin biosynthesis

The Cu-catalysed reaction of the substituted 3-phenylthiopropianamide with di-t-butyl peroxide gives the β-lactam via oxidative cyclisation of the α-thioalkyl radical. Similar reactions of the propionamides with t-butyl perbenzoate give benzoates which can be readily converted into the β-lactams, but neither β-lactams nor benzoates can be obtained from the thiazepines. Dimethyl disulfide is benzoyloxylated on treatment with t-butyl perbenzoate. The relevance of these results to penicillin biosynthesis is discussed.