20641-24-1

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 762-04-9 Diethyl phosphonate 
• 873-75-6 4-bromobenzenemethanol 

Downstream Products

• 57787-11-8 diethyl α-chloro-4-bromobenzylphosphonate 
• 1181811-90-4 diethyl α,α-chlorofluoro-4-bromobenzylphosphonate 
• 189180-13-0 [Amino-(4-bromo-phenyl)-methyl]-phosphonic acid diethyl ester 
• 335197-65-4 [Azido-(4-bromo-phenyl)-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

Choline hydroxide has been found to be an efficient basic ionic liquid catalyst for the synthesis of α-hydroxyphosphonates. Hydrophosphonylation of aldehydes was performed via the nucleophilic addition of diethylphosphite to aldehydic carbonyl compounds, in the presence of choline hydroxide under neat as well as solvent conditions. A wide array of substrates, including aromatic, fused aromatic, and heterocyclic aldehydes, were efficiently converted to their corresponding products in good yields. This protocol provides an alternative method for the straightforward synthesis of α-hydroxyphosphonates in high yields.

Syntheses of bimetallic rare-earth bis(cyclopentadienyl) derivatives supported by bridged bis(guanidinate) ligands and their catalytic property for the hydrophosphonylation of aldehydes

Some bimetallic rare earth bis(cyclopentadienyl) derivatives supported by bridged bis(guanidinate) ligands {(C5H5)2RE[(RN)2CN(CH2)2]}2 [R = iPr, RE = Yb(1), Er(2), Y(3

Synthesis and characterization of ytterbium guanidinates stabilized by bridged bis(phenolate) ligand and their application for the hydrophosphonylation reaction of aldehydes

A series of ytterbium guanidinato complexes stabilized by an amine-bridged bis(phenolate) ligand were prepared, and their catalytic property for the hydrophosphonylation reaction of aldehydes was explored. Metathesis reactions of amine-bridged bis(phenola

Syntheses of bimetallic lanthanide bis(amido) complexes stabilized by bridged bis(guanidinate) ligands and their catalytic activity toward the hydrophosphonylation reaction of aldehydes and ketones

A series of bimetallic lanthanide bis(amido) complexes stabilized by bridged bis(guanidinate) ligands {[(Me3Si)2N]2Ln[(RN)2-CN(CH2)2]}2 [R= i Pr, Ln=Sm (1), Yb (2), Y

MgO-coated-Fe3O4 nanoparticles as a magnetically recoverable and reusable catalyst for the synthesis of 1-hydroxyphosphonates

Nanosize magnetic particles coated with magnesium oxide (core/shell nanoparticles) have been prepared and used for the synthesis of 1-hydroxyalkyl phosphonates. Catalytic activity studies show that the magnetic particles coated with magnesium oxide have h

Lanthanide anilido complexes: Synthesis, characterization, and use as highly efficient catalysts for hydrophosphonylation of aldehydes and unactivated ketones

Lanthanide anilido complexes stabilized by the 2,6-diisopropylanilido ligand have been synthesized and characterized, and their catalytic activity for hydrophosphonylation reaction was explored. A reaction of anhydrous LnCl 3 with 5 equivalents

N -BuLi as a highly efficient precatalyst for hydrophosphonylation of aldehydes and unactivated ketones

It was found for the first time that organic alkali metal compounds serve as highly efficient precatalysts for the hydrophosphonylation reactions of aldehydes and unactivated ketones with dialkyl phosphite under mild conditions. For ketone substrates, a reversible reaction was observed, and the influence of catalyst loading and reaction temperature on the reaction equilibrium was studied in detail. Overall, the hydrophosphonylation reactions catalyzed by 0.1 mol % n-BuLi were completed within 5 min for a broad range of substrates and generated a series of α-hydroxy phosphonates in high yields.

Synthesis and characterization of amidate rare-earth metal amides and their catalytic activities toward hydrophosphonylation of aldehydes and unactivated ketones

Two novel amidate rare-earth metal amides Ln[N(SiMe3)2](κ2-L1)2(THF) (L1 = C6H5C(O)NC6H3(iPr)2) (Ln = Yb (1), Y (2)) were p

Copper-catalyzed synthesis of α-hydroxy phosphonates from H-phosphonates and alcohols or ethers

Easy PC: α-Hydroxy phosphonates were synthesized by copper/tert-butyl hydroperoxide (TBHP)-catalyzed oxidative addition reactions of H-phosphonates with alcohols or ethers. Diverse α-hydroxy phosphonates were obtained from substituted benzyl alcohols or alkyl alcohols and alkyl ethers in moderate to good yields. Copyright

Lanthanide amido complexes incorporating amino-coordinate-lithium bridged bis(indolyl) ligands: Synthesis, characterization, and catalysis for hydrophosphonylation of aldehydes and aldimines

Two series of new lanthanide amido complexes supported by bis(indolyl) ligands with amino-coordinate-lithium as a bridge were synthesized and characterized. The interactions of [(Me3Si)2N] 3LnIII(μ-Cl)Li(THF)su