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206443-06-3

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206443-06-3 Usage

Description

4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. It is a white solid that exhibits pH-dependent fluorescence, with excitation maxima of 320 and 360 nm at low and high pH, respectively, and an emission maximum ranging from 445 to 455 nm.

Uses

Used in Enzyme Activity Assays:
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) is used as a substrate for the determination of galactose-6-sulfate sulfatase activity. It is cleaved by the enzyme to release the fluorescent moiety 4-MU, allowing for the quantification of enzyme activity.
Used in Lysosomal Storage Disorder Diagnosis:
4-MU-Gal-6S is used in the diagnosis of Mucopolysaccharidosis IV A (Morquio disease type A), a lysosomal storage disorder characterized by a deficiency of GALNS enzyme activity. The substrate can be used to assess GALNS activity in a very small blood volume, helping to determine the extent of deficiency.
Used in Research and Development:
4-MU-Gal-6S is utilized in research and development for the study of lysosomal storage disorders, enzyme kinetics, and the development of potential therapeutic agents targeting GALNS deficiency. Its fluorescence properties make it a valuable tool for monitoring enzyme activity and screening for potential enzyme modulators.

Check Digit Verification of cas no

The CAS Registry Mumber 206443-06-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,4,4 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 206443-06:
(8*2)+(7*0)+(6*6)+(5*4)+(4*4)+(3*3)+(2*0)+(1*6)=103
103 % 10 = 3
So 206443-06-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H18O11S.Na/c1-7-4-12(17)26-10-5-8(2-3-9(7)10)25-16-15(20)14(19)13(18)11(27-16)6-24-28(21,22)23;/h2-5,11,13-16,18-20H,6H2,1H3,(H,21,22,23);/q;+1/p-1/t11?,13-,14-,15-,16+;/m0./s1/rC16H17NaO11S/c1-7-4-12(18)26-10-5-8(2-3-9(7)10)25-16-15(21)14(20)13(19)11(27-16)6-24-29(22,23)28-17/h2-5,11,13-16,19-21H,6H2,1H3/t11?,13-,14-,15-,16+/m0/s1

206443-06-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Sodium 4-methyl-2-oxo-2H-chromen-7-yl (5ξ)-6-O-sulfonato-α-L-ribo -hexopyranoside

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:206443-06-3 SDS

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