206532-40-3Relevant academic research and scientific papers
Expeditious synthetic route to B-ring functionalised 2-oxa-steroids: Synthesis of 17-ethylenedioxy-6α-hydroxy-2-oxa-4-androsten-3-one as key synthon
Nangia, Ashwini,Anthony
, p. 1113 - 1118 (2007/10/03)
The easily prepared 17-ethylenedioxy-4-androsten-3,6-dione 8 is transformed to 17-ethylenedioxy-6α-hydroxy-2-oxa-4-androsten-3-one 15 in a few steps with complete stereo- and regio-control. The hydroxylactone 15 provides an easy entry to B-ring functionalised 2-oxa-androgens for evaluation as potential aromatase inhibitors and anabolic agents.
