206532-55-0

Upstream product

• 100-53-8 phenylmethanethiol 
• 206532-50-5 (S)-(+)-2-carboxymethyl-2-methyl-4-butanolide 
• 226249-55-4 (S)-(+)-2-methyl-2-(2-oxopropyl)-4-butanolide 
• 172275-32-0 (S)-2-methyl-2-<(E)-2-nitropropenyl>-4-butanolide 

Downstream Products

• 39122-19-5 ethosuximide 
• 206532-57-2 (R)-3-(2-Benzylsulfanyl-ethyl)-3-methyl-pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

A new divergent asymmetric synthesis of (+)- and (-)-ethosuximides and their anticonvulsant activities

Both enantiomers of ethosuximide were synthesized divergently from nitroolefin lactone [(-)-2a] or [(-)-2b], which was obtained by asymmetric nitroolefination of α-methyl-γ-butyrolactone with chiral nitro enamines derived from L-proline. Although anticonv

Synthesis of (+)- and (-)-ethosuximides utilizing asymmetric nitroolefination

Both enantiomers of ethosuximide were synthesized from (S)-(-)- and (R)-(+)-2-methyl-2-[(E)-2-nitroethenyl]-γ-butyrolactones (1), which were obtained by asymmetric nitroolefination of α-methyl-γ-butyrolactone, via the lactone carboxylic acid (3).