206548-13-2

Basic information

• Product Name: 2-AMINO-5-BROMO-3-METHYLBENZOIC ACID
• Synonyms: 2-AMINO-5-BROMO-3-METHYLBENZOIC ACID;BUTTPARK 76\07-03
• CAS NO: 206548-13-2
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.06
• Mol File: 206548-13-2.mol

Chemical Properties

• Melting Point: 236-238°C
• Boiling Point: 347.859 °C at 760 mmHg
• Flash Point: 164.18 °C
• Appearance: /
• Density: 1.682
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.62±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-BROMO-3-METHYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMO-3-METHYLBENZOIC ACID(206548-13-2)
• EPA Substance Registry System: 2-AMINO-5-BROMO-3-METHYLBENZOIC ACID(206548-13-2)

Safety Data

• Hazardous Substances Data: 206548-13-2(Hazardous Substances Data)

Usage

Uses

2-AMINO-5-BROMO-3-METHYLBENZOIC ACID is a useful research chemical.

Upstream product

• 77395-10-9 5-bromo-7-methyl-2,3-d1H ydro-1H-indole-2,3-dione 
• 583-75-5 4-Bromo-2-methylaniline 
• 95-53-4 o-toluidine 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 4389-45-1 3-methylantranilic acid 

Downstream Products

• 1217506-31-4 C₂₀H₁₅BrClF₃N₄O₄ 
• 206548-14-3 2-Amino-5-bromo-3-methyl-benzoic acid methyl ester 
• 908597-10-4 2,5-dibromo-3-methyl benzoic acid methyl ester 
• 908597-09-1 2,5-dibromo-3-methylbenzoic acid 
• 898747-24-5 methyl 5-bromo-1H-indazole-7-carboxylate 
• 890707-30-9 2-amino-5-bromo-N,3-dimethylbenzamide 
• 695204-50-3 C₁₁H₁₂BrNO₃ 
• 1360957-64-7 (5-bromo-1H-indazol-7-yl)methanol 

Relevant articles and documents

A PROCESS FOR THE SYNTHESIS OF ANTHRANILIC ACID/AMIDE COMPOUNDS AND INTERMEDIATES THEREOF

The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, wherein, R, R1, R2, R3 and R10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4

The present invention relates to novel quinazolinone derivatives of formula (I) as well as pharmaceutical compositions containing these compounds. The compounds of formula (I) as provided herein can act as positive allosteric modulators of metabotropic glutamate receptor subtype 4 (mGluR4), and can thus be used as therapeutic agents, particularly in the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions or conditions which can be affected by alteration of glutamate level or signalling.

ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

A cyano sulphone containing N - (sulfur) imine O-formyl amino benzamide derivatives and its preparation and use

The invention provides o-formylamino benzamide derivatives containing N-cyano sulfone(sulfur)imine, a preparation method thereof and uses thereof. The invention relates to bisamide derivatives containing pyrazolecarboxamide, and the general chemical formula of the derivatives is shown as the formula I. The invention discloses a general structural formula and synthesis methods of the compounds, uses of the compounds serving as insecticides, bactericides, plant virus resisting agents and plant activators, and processing processes for the compounds in the preparation of the insecticides, the bactericides, the plant virus resisting agents and the plant activators in a manner of being mixed with agriculturally-acceptable assistants or synergists. The invention further discloses uses of combination of the compounds with the commercial insecticides, bactericides, plant virus resisting agents and plant activators in the prevention and treatment of the diseases, insect pests and viral diseases in agriculture, forestry and horticulture and a preparation method thereof.

The therapeutic compound, use and related method (by machine translation)

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition containing a compound or its salt which prevents or treats a central nervous system disease in which integration dysfunction syndrome and agnosia are enumerated as exemplary disorders.SOLUTION: The pharmaceutical composition includes the compound or its salt represented by chemical formula (A) which modulates striatal-enriched protein tyrosine phosphatase (STEP).

Containing sulfide, N-cyano-sulfur (sulfone) imine structure substituted pyrazole carboxamides double-amide derivatives and process for their preparation and use

The invention provides a double amide derivative containing a sulfur ether and N-sulfur cyano (sulphone) imine structure and replacing pyrazolecarboxamide and a preparing method and purpose thereof, and relates to double amide derivatives containing the pyrazolecarboxamide. The double amide derivative containing the pyrazolecarboxamide has a chemical structure general formula as shown in the map I. The structure general formula and the synthetic method of the double amide derivative and the purpose for being used as insecticides, antiseptics, a plant virus resistance agent and a plant activator are disclosed. The double amide derivative containing the sulfur ether and N-sulfur cayano (sulphone) imine structure and replacing the pyrazolecarboxamide can be mixed with auxiliaries or synergists which are acceptable in agriculture to form a processing technology to be used for preparing the insecticides, the antiseptics, the plant virus resistance agent and the plant activator. The invention further discloses the purpose and preparing method of the double amide derivative containing the sulfur ether and N-sulfur cyano (sulphone) imine structure and replacing the pyrazolecarboxamide combining with commodity insecticides, commodity antiseptics, commodity plant virus resistance agents and commodity plant activators to be used for preventing and curing plant diseases, insect pests, virus diseases in agriculture, forestry and horticulture.

Design, Synthesis, and Biological Screening of Novel Anthranilic Diamides

Three series of new anthranilic diamide derivatives containing sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine groups were designed and synthesized by combining the active substructures of anthranilic diamides and sulfoxaflor. The structures of all newly synthesized compounds were confirmed by IR and 1H/13C-NMR, and some of them were confirmed by elemental analysis or HRMS too. The synthesized compounds were screened for their insecticidal and fungicidal activities. Bioasssay results indicated that some of the synthesized compounds possessed certain degrees of insecticidal activity against Mythimna separata. However, some compounds exhibited good fungicidal activity against Sclerotinia sclerotiorum.

QUINAZOLINEDIONE DERIVATIVE

The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE

Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are described herein. Exemplary disorders include schizophrenia and cognitive deficit.

QUINAZOLINE INHIBITORS OF PI3K

The invention is directed to compounds of formula I: and pharmaceutically acceptable salts as well as methods of making and using the compounds to inhibit PI3K.