206550-41-6Relevant academic research and scientific papers
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Levin,Du,DiJoseph,Killar,Sung,Walter,Sharr,Roth,Moy,Powers,Jin,Cowling,Skotnicki
, p. 235 - 238 (2007/10/03)
A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.
