206563-13-5Relevant academic research and scientific papers
Dioxygenase-catalyzed cis-dihydroxylation of pyridine-ring systems
Boyd, Derek R.,Sharma, Narain D.,Modyanova, Ludmila V.,Carroll, Jonathan G.,Malone, John F.,Allen, Christopher C.R.,Hamilton, John T.G.,Gibson, David T.,Parales, Rebecca E.,Dalton, Howard
, p. 589 - 600 (2007/10/03)
Toluene dioxygenase-catalyzed dihydroxylation, in the carbocyclic rings of quinoline, 2-chloroquinoline, 2-methoxyquinoline, and 3-bromoquinoline, was found to yield the corresponding enantiopure cis-5,6- and -7,8-dihydrodiol metabolites using whole cells
Dioxygenase-catalysed cis-dihydrodiol formation in the carbo- and hetero-cyclic rings of quinolines
Boyd,Sharma,Carroll,Malone,Mackerracher,Allen
, p. 683 - 684 (2007/10/03)
Evidence of enzyme-catalysed cis-dihydroxylation in the pyridine (3,4-bond) and benzene rings (5,6- and 7,8-bonds) of quinoline and 2-substituted quinolines is examined in light of the isolation of a heterocyclic cis-diol derivative of 2-quinolone, as a single enantiomer of opposite absolute configuration to that found for the enantiopure carbocyclic cis-diol metabolites from quinolines.
