20659-79-4

Upstream product

• 1809-04-7 (S)-(+)-2-iodooctane 
• 53178-41-9 2-lithio-2-phenyl-1,3-dithiane 
• 344317-09-5 2-Dimethylamino-3-methyl-2-phenyl-nonanenitrile 
• 1221065-40-2 (S,E)-2-methyl-1-phenyloct-3-en-1-one 
• 827-36-1 2-(N,N-dimethylamino)-2-phenylacetonitrile 
• 1191-24-8 (S)-(+)-2-bromooctane 

Downstream Products

• 66226-28-6 (R)-2-Methyl-1,1-diphenyl-octan-1-ol 
• 79912-72-4 (1R,2R)-2-Methyl-1-phenyl-octan-1-ol 
• 79912-76-8 (1S,2R)-2-Methyl-1-phenyl-octan-1-ol 

Relevant academic research and scientific papers

Enantioselective alkenylation via nickel-catalyzed cross-coupling with organozirconium reagents

A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary a-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile β,-unsaturated ketones with good enantioselectivity.

Palladium-Catalyzed Reaction of Acyliron Complexes with Aryl Halydes. A Convenient Synthesis of Aromatic Ketones

Acyliron complexes, easily prepared from disodium tetracarbonylferrate and alkyl halides, reacted with aryl iodides in the presence of a catalytic amount of Pd(PPh3)4 and a cocatalyst, ZnCl2, to give aromatic ketones in good yields. (R)-2-Methyl-1-phenyl-octanone was prepared starting from (S)-2-bromooctane in an excellent optical yield.

The Stereochemistry of Alkylation of α-Aminonitrile Anions by Chiral 1-Methylheptyl Halides

The alkylation of the α-dimethylaminophenylacetonitrile with chiral 1-methylheptyl halides in liquid ammonia involves a partial inversion of the configuration.The accompanying racemization is dependent on the basic reagent and is the consequence of partia