20662-94-6

Basic information

• Product Name: 2-Ethyl-4,5-diphenyloxazole
• Synonyms: 2-Ethyl-4,5-diphenyloxazole
• CAS NO: 20662-94-6
• Molecular Formula: C₁₇H₁₅NO
• Molecular Weight: 249.31
• Mol File: 20662-94-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 31-32 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• Boiling Point: 110-125 °C(Press: 0.3 Torr)
• Appearance: /
• Density: 1.089±0.06 g/cm3(Predicted)
• PKA: 1.24±0.10(Predicted)
• CAS DataBase Reference: 2-Ethyl-4,5-diphenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethyl-4,5-diphenyloxazole(20662-94-6)
• EPA Substance Registry System: 2-Ethyl-4,5-diphenyloxazole(20662-94-6)

Safety Data

• Hazardous Substances Data: 20662-94-6(Hazardous Substances Data)

Upstream product

• 53901-50-1 α-propionyloxy-deoxybenzoin 
• 14224-99-8 2-methyl-4,5-diphenyloxazole 
• 74-88-4 methyl iodide 
• 7664-93-9 sulfuric acid 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 107-12-0 propiononitrile 
• 16483-98-0 2,3-diphenyl-2H-azirine 
• 79-05-0 Propionamid 
• 87696-44-4 4,5-diphenyl-2-(5-hexenyl)oxazole 
• 41260-60-0 2-hydroxy-1-phenyl-2-propionylamino-ethanone 
• 71-43-2 benzene 
• 14725-35-0 2-methylthio-4,5-diphenyl-1,3-oxazole 
• 925-90-6 ethylmagnesium bromide 
• 451-40-1 phenyl benzyl ketone 

Downstream Products

• 28358-79-4 N-propionyl-benzamide 

Relevant articles and documents

Iron-Catalyzed Cycloaddition of Amides and 2,3-Diaryl-2 H-azirines to Access Oxazoles via C-N Bond Cleavage

A novel and efficient iron-catalyzed cycloaddition reaction using readily available 2,3-diaryl-2H-azirines and primary amides is reported. A wide range of trisubstituted oxazoles could be achieved in good yields with good functional group compatibility. In this transformation, two C-N bonds were cleaed and new C-N and C-O bonds were formed.

Synthesis of Extended Oxazoles III: Reactions of 2-(Phenylsulfonyl)methyl-4,5-diaryloxazoles

2-((Phenylsulfonyl)methyl)-4,5-diphenyloxazole is a useful scaffold for synthetic elaboration at the 2-methylene position thereby affording extended oxazoles. The corresponding α-sulfonyl anion reacts smoothly with diverse alkyl halides giving monoalkylated (47-90%), dialkylated (50-97%), and cyclic (59-93%) products. The reductive desulfonylation of the monoalkylated and selected dialkylated products was optimized with a magnesium/mercuric chloride reagent system and afforded desulfonylated products in the range of 66-97%. The anti-inflammatory Oxaprozin was prepared using the α-sulfonyl carbanion strategy along with optimized desulfonylation.

Synthesis of 2-substituted 4,5-diphenyloxazoles under solvent-free microwave irradiation conditions

A novel method for the direct conversion of deoxybenzoin into 2-alkyl-4,5-diphenyloxazoles and 2-aryl-4,5-diphenyloxazoles has been developed using treatment of HTIB and nitriles under solvent-free microwave irradiation conditions. Copyright Taylor & Fran