206649-15-2Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents
Li, Ling,Quan, Dongling,Chen, Jingxuan,Ding, Jiahao,Zhao, Jinwu,Lv, Lin,Chen, Jianjun
, (2019/10/14)
A series of novel 1-substituted-2-aryl imidazoles (SAI) were designed and synthesized based on our previously reported ABI (2-Aryl-4-Benzoyl Imidazole) analogs and on the structure of combretastatin A-4 (CA-4). These compounds showed potent antiproliferat
Benzoic acid derivatives and application thereof
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Paragraph 0033; 0034; 0035; 0036, (2019/04/04)
The invention relates to benzoic acid derivatives. The chemical structure of the benzoic acid derivatives is shown as formula (I) in the description, wherein in the formula (I), X is O or NH; R is3,4,5-trimethoxy, 3-nitro-4-methoxy or 3-amino-4-methoxy
3-AMIDOBENZAMIDES AND USES THEREOF FOR INCREASING CELLULAR LEVELS OF A3G
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Paragraph 0084; 0085; 0086; 0087; 0090; 0091, (2016/03/13)
Disclosed are novel benzamide compounds and the uses thereof for treating diseases and disorders in a patient in need thereof by increasing cellular levels of A3G and/or other members of the A3 family of proteins in the patient. The disclosed compounds in
3-(2′-Bromopropionylamino)-benzamides as novel S-phase arrest agents
Hu, Laixing,Li, Zhuo-rong,Li, Jian-Nong,Qu, Jinrong,Jiang, Jian-Dong,Boykin, David W.
, p. 6847 - 6852 (2008/09/16)
We report the synthesis, antiproliferative activity, and SAR of novel 3-(2′-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent cytotoxicities against Molt-3 leukemia cells. Several compounds exihibited cytotoxicities (under 6.5
Syntheses and antitumor activity of cis-restricted combretastatins: 5- membered heterocyclic analogues
Ohsumi, Koji,Hatanaka, Toshihiro,Fujita, Koichi,Nakagawa, Ryusuke,Fukuda, Yumiko,Nihei, Yukio,Suga, Yasuyo,Morinaga, Yoshihiro,Akiyama, Yukio,Tsuji, Takashi
, p. 3153 - 3158 (2007/10/03)
A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds 16 and 35 showed marked tumor growth suppression in the colon 26 murine tumor model.
