206650-01-3Relevant academic research and scientific papers
Synthesis of novel 3′-C-branched 2′-deoxynucleosides. Incorporation of 3′-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides
Pfundheller, Henrik M.,Jorgensen, Pia N.,Sorensen, Ulrik S.,Sharma, Sunil K.,Grimstrup, Marie,Stroech, Claudia,Nielsen, Poul,Viswanadham, Garimella,Olsen, Carl Erik,Wengel, Jesper
, p. 1409 - 1421 (2007/10/03)
The methyl glycoside derivatives 4, 6,10 and 32 have been used as precursors for the synthesis of novel 3′-C-alkyl-modified α- and β-2′-deoxynucleosides. Using an alternative linear strategy, 3′-C-methyl- and 3′-C-azidomethyl-modified thymidines 16 and 17 have been synthesized. Hybridization experiments with oligodeoxynucleotides containing 3′-C-(3-hydroxypropyl)thymidine monomers are reported.
