2067-33-6

Basic information

• Product Name: 5-Bromovaleric acid
• Synonyms: Valeric acid, 5-bromo- (6CI,7CI,8CI);1-Bromo-4-carboxybutane;5-Bromo-1-pentanoic acid;5-Bromopentanoic acid;Pentanoic acid, 5-bromo-;d-Bromovaleric acid
• CAS NO: 2067-33-6
• Molecular Formula: C₅H₉BrO₂
• Molecular Weight: 180.0204
• EINECS: 218-185-3
• Product Categories: fine chemicals;Organic acids;Acids & Esters;Bromine Compounds;omega-Bromocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;C1 to C5;Carbonyl Compounds;Carboxylic Acids
• Mol File: 2067-33-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 38-40℃
• Boiling Point: 265.5 °C at 760 mmHg
• Flash Point: 114.4 °C
• Appearance: yellowish to light brown crystals or cryst. powder
• Density: 1.522 g/cm³
• Vapor Pressure: 0.00264mmHg at 25°C
• Refractive Index: 1.4790 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 95% ethanol: soluble50mg/mL, clear, colorless to faintly yellow
• PKA: 4?+-.0.10(Predicted)
• Water Solubility: Soluble in ethanol. Insoluble in water.
• BRN: 1745664
• CAS DataBase Reference: 5-Bromovaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromovaleric acid(2067-33-6)
• EPA Substance Registry System: 5-Bromovaleric acid(2067-33-6)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S36:
• RIDADR: UN3261
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2067-33-6(Hazardous Substances Data)

Usage

Chemical Properties

yellowish to light brown crystals or cryst. powder

Uses

Different sources of media describe the Uses of 2067-33-6 differently. You can refer to the following data:
1. 5-Bromovaleric acid is used in the synthesis of inhibitors for aminoglycoside resistant bacteria. 5-Bromovaleric acid is also used in the preparation of sequence specific base pair mimics as topoisomerase IB inhibitors.
2. 5-Bromovaleric acid was used in the preparation of:5-(3-dimethylammonio)propylammonio pentanoate bromide via reaction with 1,1-dimethyl-1,3-propylenediaminenanodiamond functionalized by carboxylic acid groupswater-soluble nanoplatelets of potassium graphite

Purification Methods

Crystallise the acid from pet ether. [Beilstein 2 IV 883.]

InChI:InChI=1/C5H9BrO2/c6-4-2-1-3-5(7)8/h1-4H2,(H,7,8)/p-1

Synthetic route

5-bromopentanal (1191-30-6) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; for 3h; Schlenk technique;	95%
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; under 760.051 Torr; for 3h; Catalytic behavior; Solvent; Schlenk technique;	95%

potassium 5-hydroxypentanoate → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With sulfuric acid; sodium bromide In water at 90 - 95℃; for 8h; Temperature; Concentration;	88.9%

3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With tetrabutylammomium bromide; hydrogen bromide In water for 0.166667h; Microwave irradiation;	85%
With sulfuric acid; water; hydrogen bromide
With hydrogen bromide

1,4-dioxane (123-91-1) + 3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9) → 5-bromopentanoic acid (2067-33-6) + β-(β'-bromoethoxy)ethyl 4-bromovalerate (91034-94-5)

Conditions	Yield
With hydrogen bromide In water 1) room temp. 1h; 2) 80 degC, 1,5h; 3) room temp. 12h;	A 64.12% B 20.24%

3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9) → 5-bromopentanoic acid (2067-33-6) + β-(β'-bromoethoxy)ethyl 4-bromovalerate (91034-94-5)

Conditions	Yield
With hydrogen bromide In 1,4-dioxane; water 1) room temp. 1 h; 2) 80 deg C, 1,5 h; 3) room temp. 12 h;	A 64.12% B 20.24%

5-bromopentan-1-nitrile (5414-21-1) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide for 17h; Heating;	38%
With hydrogen bromide
With hydrogen bromide
Multi-step reaction with 2 steps 1: potassium hydroxide 2: water; hydrobromic acid View Scheme
Multi-step reaction with 2 steps 2: water; hydrobromic acid View Scheme

pent-4-enoic acid (591-80-0) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide; dibenzoyl peroxide
With ascaridole; hexane; hydrogen bromide

valeric acid (13392-69-3) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With sulfuric acid; hydrogen bromide
With sulfuric acid; hydrogen bromide Cooling with ice; Heating;

5-hydroxy-pentanenitrile (2427-16-9) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With water; hydrogen bromide

5-ethoxy-valeronitrile (6067-01-2) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With water; hydrogen bromide

5-bromovaleric acid methyl ester (5454-83-1) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide
(hydrolysis);

ethyl 2-hydroxyethylpropionate (13107-53-4) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With sulfuric acid; hydrogen bromide zuletzt auf dem Wasserbad;

(4-cyano)butyl acetate (89775-53-1) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With water; hydrogen bromide

diethyl 2-(3-bromopropane)malonate (10149-21-0) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide

5-phenoxyvaleric acid (7170-40-3) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide

(3-phenoxypropyl)diethyl propanedioate (6345-89-7) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide

cyclopentanone (120-92-3) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With dihydrogen peroxide Behandeln des Reaktionsprodukts in Aether mit einer aus Kupfer(I)-chlorid (oder Eisen(II)-sulfat) und wss.Bromwasserstoffsaeure bereiteten Loesung;
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / chloroform / Reflux 2: hydrogen bromide; sodium bromide; sulfuric acid / 85 - 90 °C View Scheme

ethyl 5-bromovalerate (14660-52-7) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
(hydrolysis);
With water; lithium hydroxide In methanol at 20℃; for 0.5h;

cyclopentanone hydroperoxide (18622-31-6) → 5-bromopentanoic acid (2067-33-6) + α,α'-dibromocyclopentanone + 2-bromocyclopentanone (1056246-36-6)

Conditions	Yield
With hydrogen bromide; sodium bromide; copper(ll) bromide In water at 25℃;	A 15.0 g B 0.4 g C 0.6 g

C17H34O2Sn (110328-07-9) → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide Irradiation;

δ-iodo-valeric acid → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With silver(I) bromide; hydrogen bromide

δ-phenoxy-valeric acid → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide at 145℃; im geschlossenen Rohr;

pent-4-enoic acid (591-80-0) + hexane (110-54-3) + hydrogen bromide (10035-10-6, 12258-64-9) → 5-bromopentanoic acid (2067-33-6)

ascaridole (512-85-6) + pent-4-enoic acid (591-80-0) + hexane (110-54-3) + hydrogen bromide (10035-10-6, 12258-64-9) → 5-bromopentanoic acid (2067-33-6)

pent-4-enoic acid (591-80-0) + hydrogen bromide (10035-10-6, 12258-64-9) + diphenylamine (122-39-4) → 5-bromopentanoic acid (2067-33-6)

5-bromo-valeric acid alkyl ester → 5-bromopentanoic acid (2067-33-6)

Conditions	Yield
With hydrogen bromide; acetic acid

pent-4-enoic acid (591-80-0) + hydrogen bromide (10035-10-6, 12258-64-9) + hydroquinone (123-31-9) → 5-bromopentanoic acid (2067-33-6)

pent-4-enoic acid (591-80-0) + hydrogen bromide (10035-10-6, 12258-64-9) + toluene (108-88-3) → 5-bromopentanoic acid (2067-33-6)

pent-4-enoic acid (591-80-0) + hydrogen bromide (10035-10-6, 12258-64-9) + dibenzoyl peroxide (94-36-0) → 5-bromopentanoic acid (2067-33-6)

5-bromopentanoic acid (2067-33-6) → 5-iodopentanoic acid (19448-36-3)

Conditions	Yield
With potassium iodide In acetone for 6h; Heating;	100%
With acetone; sodium iodide
Multi-step reaction with 2 steps 1: KHS 2: hydriodic acid View Scheme

5-bromopentanoic acid (2067-33-6) → 5-bromovaleroyl chloride (4509-90-4)

Conditions	Yield
With thionyl chloride	100%
With oxalyl dichloride In benzene at 20 - 50℃; Inert atmosphere;	98%
With oxalyl dichloride In benzene at 50℃; for 3h;	97%

1-[5-(aminomethyl)-2-nitrophenyl]ethanol (138957-91-2) + 5-bromopentanoic acid (2067-33-6) → 1-[5-{N-(5-bromopentanoyl)aminomethyl}-2-nitrophenyl]ethanol

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h;	100%

methanol (67-56-1) + 5-bromopentanoic acid (2067-33-6) → 5-bromovaleric acid methyl ester (5454-83-1)

Conditions	Yield
With acetyl chloride for 5h; Reflux;	99%
With hydroxy-substituted sulfonic acid-functionalized silica (HO-SAS) at 110℃; Fischer-Speier Esterification; Flow reactor;	99%
With acetyl chloride for 5h; Reflux;	99%

5-bromopentanoic acid (2067-33-6) + (3R,5R)-1-benzyl-5-(hydroxydiphenylmethyl)pyrrolidin-3-ol → (3R,5R)-1-benzyl-5-(hydroxydiphenylmethyl)pyrrolidin-3-yl 5-bromopentanoate (1233938-88-9)

Conditions	Yield
Stage #1: 5-bromopentanoic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.166667h; Stage #2: (3R,5R)-1-benzyl-5-(hydroxydiphenylmethyl)pyrrolidin-3-ol In dichloromethane at 0℃; for 1.5h; Reflux;	99%

5-bromopentanoic acid (2067-33-6) + isobutene (115-11-7) → tert-butyl 5-bromovalerate (88987-42-2)

Conditions	Yield
With sulfuric acid at 20℃; for 5h; Addition;	98%
With sulfuric acid In dichloromethane for 48h; Ambient temperature;	96%
With sulfuric acid at 20℃; for 120h; autoclave;	72%

5-bromopentanoic acid (2067-33-6) → 5-bromopentanamide (52534-24-4)

Conditions	Yield
Stage #1: 5-bromopentanoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 40℃; for 2h; Stage #2: With ammonium hydroxide In tetrahydrofuran at 20℃; for 2h;	98%
Multi-step reaction with 2 steps 1: SOCl2 / 4 h / Heating 2: 28percent NH4OH / H2O / 0.75 h / 0 °C View Scheme

2-(N,N-dimethylamino)ethanol (108-01-0) + 5-bromopentanoic acid (2067-33-6) + (3Z,13Z)-7-[(3Z)-hex-3-en-1-yl]-10-[(3Z)-non-3-en-1-yl]nonadeca-3,13-dien-9-ol → (3Z,13Z)-7-[(3Z)-hex-3-en-1-yl]-10-[(3Z)-non-3-en-1-yl]nonadeca-3,13-dien-9-yl 5-(dimethylamino)pentanoate

Conditions	Yield
Stage #1: 5-bromopentanoic acid; (3Z,13Z)-7-[(3Z)-hex-3-en-1-yl]-10-[(3Z)-non-3-en-1-yl]nonadeca-3,13-dien-9-ol With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 30℃; for 18h; Stage #2: 2-(N,N-dimethylamino)ethanol In dichloromethane at 80℃; for 5h; Sealed tube;	98%

5-bromopentanoic acid (2067-33-6) + Benzophenone oxime (574-66-3) → diphenylmethanone O-(5-bromopentanoyl) oxime

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Schlenk technique; Inert atmosphere;	98%

5-bromopentanoic acid (2067-33-6) + (3R,5S)-1-benzyl-5-[bis(3,5-dimethylphenyl)(hydroxy)methyl]pyrrolidin-3-ol (1262967-61-2) → {(3R,5S)-1-benzyl-5-[bis(3,5-dimethylphenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate (1262967-63-4)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 1.66667h; Reflux;	97%

5-bromopentanoic acid (2067-33-6) → 5-(nitrooxy)pentanoic acid (74754-56-6)

Conditions	Yield
With silver nitrate In acetonitrile at 70℃; for 16h;	96.18%
With silver nitrate In acetonitrile at 20℃; for 48h;	89%
With silver nitrate In acetonitrile at 70℃; for 2h; Darkness; Inert atmosphere;	77%

5-bromopentanoic acid (2067-33-6) → 3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9)

Conditions	Yield
With potassium fluoride; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃; for 5h;	96%
With Amberlyst A26 (hydrogen carbonate form) 1.) aq. MeOH, 20 deg C, 18 h, 2.) THF, reflux, 18 h; Yield given. Multistep reaction;
With potassium carbonate In water; dimethyl sulfoxide at 50℃; Rate constant;
With 2,3,3-trimethylbenzo[e]indole; potassium iodide In acetonitrile at 80 - 85℃; for 96h;

5-bromopentanoic acid (2067-33-6) + triphenylphosphine (603-35-0) → (4-carboxybutyl)triphenylphosphonium bromide (17814-85-6)

Conditions	Yield
In acetonitrile at 80℃; for 24h;	96%
In acetonitrile for 24h; Heating;	92%
In toluene for 48h; Inert atmosphere; Reflux;	88%

diazomethane (186581-53-3, 908094-01-9) + 5-bromopentanoic acid (2067-33-6) → 5-bromovaleric acid methyl ester (5454-83-1)

Conditions	Yield
In diethyl ether for 3h;	96%
In diethyl ether

5-bromopentanoic acid (2067-33-6) → 5-bromopentan-1-ol (34626-51-2)

Conditions	Yield
With dimethylsulfide borane complex	96%
With lithium aluminium tetrahydride; sulfuric acid In tetrahydrofuran for 0.25h; T < 2 deg C; Yield given;
With dimethylsulfide; borane
With diphenylsilane; triphenylphosphine; chloro(1,5-cyclooctadiene)rhodium(I) dimer In tetrahydrofuran at 20℃; for 48h;	63 % Spectr.

5-bromopentanoic acid (2067-33-6) + benzyl alcohol (100-51-6) → Benzyl 5-bromovalerate (60343-28-4)

Conditions	Yield
With toluene-4-sulfonic acid In toluene Reflux; Dean-Stark;	96%
With 4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide	95%
Stage #1: 5-bromopentanoic acid With 4-(dimethylamino)pyridinium tosylate; diisopropyl-carbodiimide In dichloromethane at 20℃; for 2h; Stage #2: benzyl alcohol In dichloromethane	95%

5-bromopentanoic acid (2067-33-6) + (2S,4R)-4-hydroxy-2-(1-hydroxy-1,1-diphenylmethyl)pyrroline-1-carboxylic acid tert-butyl ester (344791-02-2) → (2S,4R)-tert-butyl 4-((5-bromopentanoyl)oxy)-2-(hydroxydiphenylmethyl)pyrrolidine-1-carboxylate

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 1.5h; Reflux;	96%

5-bromopentanoic acid (2067-33-6) + 2,2,2,-trichloroethoxycarbonyl azide → 2,2,2-trichloroethyl (4-bromobutyl)carbamate

Conditions	Yield
With dmap; copper diacetate In acetonitrile at 80℃; for 0.416667h; Schlenk technique; Sealed tube;	96%

ethanol (64-17-5) + 5-bromopentanoic acid (2067-33-6) → ethyl 5-bromovalerate (14660-52-7)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20 - 22℃; for 45h;	95%
sulfuric acid In toluene for 1.5h; Heating;	88.5%
With sulfuric acid	87%

endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide (21715-90-2) + 5-bromopentanoic acid (2067-33-6) → N-hydroxy-5-norbornene-2,3-dicarboximide bromopentanoate (872054-98-3)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide	95%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h;

5-bromopentanoic acid (2067-33-6) + (3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-ol (1262967-62-3) → {(3R,5S)-1-benzyl-5-[bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl]pyrrolidin-3-yl} 5-bromopentanoate (1262967-64-5)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 1.66667h; Reflux;	95%

5-bromopentanoic acid (2067-33-6) + n-octylmagnesium chloride (38841-98-4) → tridecanoic acid (638-53-9)

Conditions	Yield
Stage #1: 5-bromopentanoic acid With 1-methyl-pyrrolidin-2-one; tert-butylmagnesium chloride In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere; Stage #2: n-octylmagnesium chloride With buta-1,3-diene; nickel dichloride In tetrahydrofuran under 760.051 Torr; for 1h; Inert atmosphere; Cooling with ice;	95%

furan (110-00-9) + 5-bromopentanoic acid (2067-33-6) → 2-Furyl 4-bromobutyl ketone (86607-63-8)

Conditions	Yield
With trifluoroacetic anhydride; Duolite ES 467 H+ phosphonic resin In nitromethane at 25℃; for 0.5h;	94%

5-bromopentanoic acid (2067-33-6) → 5-mercaptopentanoic acid (30247-98-4)

Conditions	Yield
Stage #1: 5-bromopentanoic acid With thiourea In ethanol at 80℃; for 20h; Stage #2: With sodium hydroxide at 90℃; for 16h;	94%
Stage #1: 5-bromopentanoic acid With thiourea In ethanol for 20h; Reflux; Stage #2: With sodium hydroxide In water at 90℃; for 16h; Inert atmosphere; Stage #3: With sulfuric acid In water Cooling with ice; Inert atmosphere;	87%
Stage #1: 5-bromopentanoic acid With thiourea In ethanol for 16h; Heating; Stage #2: With sodium hydroxide for 6h; Heating;	82%

5-bromopentanoic acid (2067-33-6) + (2S,4R)-4-hydroxy-2-((S)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester → (2S,4R)-tert-butyl-2-((S)-1-phenylethylcarbamoyl)-4-(5-bromopentanoyloxy)pyrrolidine-1-carboxylate

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 1.16667h;	94%

5-bromopentanoic acid (2067-33-6) + (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol (154472-05-6) → (S)-1-phenyl-2-(piperidin-1-yl)ethyl 5-bromopentanoate

Conditions	Yield
Stage #1: (2R)-(-)-2-phenyl-2-(piperidin-1-yl)ethanol With methanesulfonyl chloride; triethylamine In chloroform at 0 - 5℃; for 0.5h; Stage #2: 5-bromopentanoic acid With triethylamine In chloroform at 5 - 20℃; for 16h; enantiospecific reaction;	94%

5-bromopentanoic acid (2067-33-6) + dibenzyl 5,5'-((1,4-phenylenebis(azanediyl))bis(carbonyl))bis(3-hydroxypyrrolidine-1-carboxylate) (1442643-45-9) → dibenzyl 5,5'-((1,4-phenylenebis(azanediyl))bis(carbonyl))bis(3-((5-bromopentanoyl)oxy)-pyrrolidine-1-carboxylate) (1442643-52-8)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 4h;	93%

5-bromopentanoic acid (2067-33-6) + N,0-dimethylhydroxylamine (1117-97-1) → 5-bromo-N-methoxy-N-methylpentanamide (130250-58-7)

Conditions	Yield
Stage #1: 5-bromopentanoic acid; N,0-dimethylhydroxylamine In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	93%

5-bromopentanoic acid (2067-33-6) + dibenzyl 5,5'-((ethane-1,2-diylbis(azanediyl))bis(carbonyl))bis(3-hydroxypyrrolidine-1-carboxylate) (1442643-48-2) → dibenzyl 5,5'-((ethane-1,2-diylbis(azanediyl))bis(carbonyl))bis(3-((5-bromopentanoyl)oxy)pyrrolidine-1-carboxylate) (1442643-54-0)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 4h;	92%

Upstream product

• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 120-92-3 cyclopentanone 
• 14660-52-7 ethyl 5-bromovalerate 
• 123-91-1 1,4-dioxane 
• 110328-07-9 C₁₇H₃₄O₂Sn 
• 110-87-2 3,4-dihydro-2H-pyran 
• 694-54-2 tetrahydro-2H-2-pyranol 
• 71195-26-1 5-chloro-3-pentenoic acid methyl ester 
• 89893-50-5 5-chloro-3-pentenoic acid ethyl ester 
• 6067-01-2 5-ethoxy-valeronitrile 
• 13392-69-3 valeric acid 
• 1191-30-6 5-bromopentanal 
• 1119-46-6 5-chloro-valeric acid 
• 4221-03-8 5-hydroxypentanal 

Downstream Products

• 30247-98-4 5-mercaptopentanoic acid 
• 13931-40-3 5-Brom-valeriansaeure-isopentylester 
• 544-74-1 octadec-6-ynoic acid 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 61168-05-6 4-carboxybutyltriphenylphosphonium iodide 
• 5454-83-1 5-bromovaleric acid methyl ester 
• 1825-61-2 Trimethylmethoxysilane 
• 6912-12-5 dimethylamine hydrobromide 
• 71541-87-2 methyl 5-(trimethylsiloxy)valerate 
• 7370-56-1 5-(benzylseleno)pentanoic acid 
• 30964-00-2 hept-6-ynoic acid 
• 34626-51-2 5-bromopentan-1-ol 
• 4509-90-4 5-bromovaleroyl chloride 

Relevant articles and documents

Preparation method of 5- bromo-n-valeryl bromide

The invention relates to a preparing method of 5-bromine pivaloyl bromide normal, belonging to the field of synthesizing methods of compounds. The preparing method of the 5-bromine pivaloyl bromide normal comprises the following steps: (1) synthesis of a midbody I: adding raw materials, i.e. m-chloroperoxybenzoic acid and drying chloroform, into a reaction kettle, and slowly adding a drying chloroform solution containing raw material cyclopentanone at room temperature so as to obtain a crude product of the midbody I; (2) synthesis of a midbody II: adding the raw material midbody I, hydrobromicacid and sodium bromide into the reaction kettle, reacting to obtain the midbody II and directly carrying out the reaction of a next step without purification; (3) synthesis of the 5-bromine pivaloylbromide normal: adding triphenylphosphine and dichloromethane into the reaction kettle, reducing the temperature to about 0 DEG C, starting to slowly add a dichloromethane solution containing bromine, adding the raw material midbody II to react, and purifying to obtain a target product, i.e. the 5-bromine pivaloyl bromide normal. The prepared product prepared by the method has higher purity and ideal yield coefficient and is suitable for being applied to industrialized production.

A aldehyde or mellow directly converted into the carboxylic acid (by machine translation)

The invention discloses a aldehyde or mellow oxidation can be directly transformed into carboxylic acid, is characterized in that the pure oxygen environment, in N - hydroxy imide compound under the catalysis of the imide compound or N - hydroxy and nitrous acid ester compound common under the catalysis, the CH2 OH and CHO oxidation directly converted into the carboxylic acid compounds. The invention using oxygen as the oxidizing agent, does not add any metal catalyst, environment-friendly, high catalytic efficiency, simple and convenient operation. With the previous metal catalytic system complex and different catalytic system, has some metal catalytic system in the process, the use of transition metal will cause the transition metal of the residual, the invention adopts the non-metallic catalytic system, environmental protection, preventing the metal residue problem, this to the solution of the drug in the synthesis of transition metal residue problem and provides a new method of thinking. (by machine translation)

Preparation method of 5-bromo-valeric acid

The invention relates to a preparation method of 5-bromo-valeric acid. The preparation method particularly includes: subjecting 5-chlorine-3-pentenoic acid ester to hydrolysis reaction, hydrogenation reaction and bromination reaction to obtain 5-bromo-valeric acid, wherein 5-chlorine-3-pentenoic acid ester is one of or multiple of 5-chlorine-3-pentenoic acid methyl ester, 5-chlorine-3-pentenoic acid ethyl ester, 5-chlorine-3-pentenoic acid propyl ester and 5-chlorine-3-pentenoic acid butyl ester. The preparation method is high in finished product yield, low in production cost, simple and easy to control and easy for industrial production, and using of high-toxicity substances like benzene and sodium cyanide is avoided, so that safety is high.