206753-46-0

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-PIPERIDIN-2-ONE
• Synonyms: 1-(4-METHOXY-PHENYL)-PIPERIDIN-2-ONE;1-(4-methoxyphenyl)-2-piperidinone
• CAS NO: 206753-46-0
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 206753-46-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 423.784 °C at 760 mmHg
• Flash Point: 210.097 °C
• Appearance: /
• Density: 1.127 g/cm³
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-PIPERIDIN-2-ONE(206753-46-0)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-PIPERIDIN-2-ONE(206753-46-0)

Safety Data

• Hazardous Substances Data: 206753-46-0(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxy-phenyl)-piperidin-2-one is a chemical compound that belongs to the class of piperidinone derivatives. It is a white solid with a molecular weight of 217.26 g/mol and a precise mass of 217.13672. 1-(4-METHOXY-PHENYL)-PIPERIDIN-2-ONE is a piperidone derivative and is a useful intermediate for the synthesis of various pharmaceutical and organic compounds. It has potential applications in the development of new drugs and therapeutic agents due to its pharmacological properties. Additionally, it is used as a building block in the development of novel compounds for medicinal and chemical research. However, further research and studies are necessary to fully understand its biological and pharmacological activities.

Upstream product

• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 104-94-9 4-methoxy-aniline 
• 675-20-7 piperidin-2-one 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 1062574-84-8 [1-(4-methoxy-phenyl)-2-oxo-piperidin-3-yl]-phosphonic acid diethyl ester 
• 474352-75-5 5-((4-methoxyphenyl)amino)pentan-1-ol 

Relevant articles and documents

Reaction of β-, γ-, and δ-chloroalkanamides with potassium tert-butoxide in tetrahydrofuran: Elimination, and lactamization

γ- and δ-Chloroalkanamides were found to undergo lactamization readily when treated with potassium tert-butoxide in tetrahydrofuran. Raising the reaction temperature may encourage SN2 displacement reaction. On the other hand β-chloroalkanamides only undergo elimination, followed by dimerization and trimerization of the acrylamide initially formed.

Synthesis of N -Aryl and N -Heteroaryl γ-, δ-, and ?-Lactams Using Deprotometalation-Iodination and N -Arylation, and Properties Thereof

Xanthone, thioxanthone, fluorenone, benzophenone, 2-benzoylpyridine, dibenzofuran, and dibenzothiophene were deprotonated using a base prepared in situ from MCl 2 ·TMEDA (M = Zn or Cd; TMEDA = N, N, N ′, N ′-tetramethylethylenediamine) and lithium 2,2,6,6-tetramethylpiperidide in a 1:3 ratio, as demonstrated by subsequent iodolysis. The different aryl halides were involved as partners in the N -arylation of pyrrolidin-2-one. In the presence of copper(I) iodide and tripotassium phosphate, and using dimethyl sulfoxide as solvent, the reactions could be performed in yields ranging from 40 to 70%. Most of the products were tested for their antimicrobial, antifungal, antioxidant, and cytotoxic (MCF-7) activity.