206883-03-6

Basic information

• Product Name: 5-(3-amino-2-chlorobenzyloxy)isoquinoline
• Synonyms: 5-(3-amino-2-chlorobenzyloxy)isoquinoline
• CAS NO: 206883-03-6
• Molecular Weight: 284.745
• Mol File: 206883-03-6.mol

Chemical Properties

• CAS DataBase Reference: 5-(3-amino-2-chlorobenzyloxy)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-amino-2-chlorobenzyloxy)isoquinoline(206883-03-6)
• EPA Substance Registry System: 5-(3-amino-2-chlorobenzyloxy)isoquinoline(206883-03-6)

Safety Data

• Hazardous Substances Data: 206883-03-6(Hazardous Substances Data)

Upstream product

• 2439-04-5 5-hydroxyisoquinoline 
• 89642-16-0 α-bromo-2-chloro-3-nitrotoluene 
• 206882-73-7 5-(2-chloro-3-nitrobenzyloxy)isoquinoline 

Downstream Products

• 206883-24-1 5-{2-chloro-3-(N,N-diacetylamino)benzyloxy}isoquinoline 

Relevant articles and documents

Studies on anti-Helicobacter pylori agents. Part 1: Benzyloxyisoquinoline derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2,6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of amoxicillin (AMPC) (1) and clarithromycin (CAM) (2). However, 10c did not show in vivo efficacy in a mouse infection model; a feature attributed to the lack of strong bactericidal activity at short contact times. (C) 1999 Elsevier Science Ltd.

Discovery of a novel benzyloxyisoquinoline derivative with potent anti- Helicobacter pylori activity

The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3- acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram- positive and Gram-negative bacteria.