20691-89-8

Basic information

• Product Name: 1-Methyl-4-piperidinemethanol
• Synonyms: CHEMBRDG-BB 4002191;BUTTPARK 145\16-21;(1-METHYL-PIPERIDIN-4-YL)-METHANOL;1-METHYL-4-PIPERIDINEMETHANOL;4-HYDROXYMETHYL-1-METHYLPIPERIDINE;N-METHYL-4-PIPERIDINEMETHANOL;N-METHYL-4-HYDROXYMETHYLPIPERIDINE;1-Methylpiperidine-4-methanol
• CAS NO: 20691-89-8
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• Product Categories: Alcohols and Derivatives;pharmacetical;Piperidine;Heterocyclic Compounds
• Mol File: 20691-89-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 108°C/10mmHg(lit.)
• Flash Point: 110℃
• Appearance: Colorless to yellow/Liquid
• Density: 0.981 g/mL at 25 °C
• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: 1-Methyl-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-piperidinemethanol(20691-89-8)
• EPA Substance Registry System: 1-Methyl-4-piperidinemethanol(20691-89-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 20691-89-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C7H15NO/c1-8-4-2-7(6-9)3-5-8/h7,9H,2-6H2,1H3

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 6457-49-4 4-piperidinemethanol 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 100-58-3 phenylmagnesium bromide 
• 24252-37-7 ethyl 1-methylisonipecotate 
• 1690-75-1 1-methyl-piperidine-4-carboxylic acid methyl ester 
• 1570-45-2 isonicotinic acid ethylester 
• 36166-75-3 1-methyl-1,2,3,6-tetrahydropyridine-4-methanol 
• 50-00-0 formaldehyd 

Downstream Products

• 1025982-21-1 C₃₉H₅₁N₅O₆ 
• 870959-63-0 3-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]benzonitrile 
• 1159928-31-0 (1-methylpiperidin-4-yl)methyl 4-nitro-phenyl carbonate 
• 853297-69-5 1-methyl-4-((4-nitro-2-(trifluoromethyl)phenoxy)methyl)piperidine 
• 646528-08-7 [3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-carbamic acid tert-butyl ester 
• 41632-36-4 4-acetoxymethyl-1,1-dimethyl-piperidinium; iodide 
• 902454-26-6 4-[(1-methylpiperidin-4-yl)methoxy]phenylamine 
• 902454-25-5 1-methyl-4-[(4-nitrophenoxy)methyl]piperidine 
• 423180-28-3 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile 

Relevant articles and documents

Diacetoxypiperidinium analogs of acetylcholine.

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PROCESS FOR PRODUCING N-METHYL OR N,N-DIMETYL AMINES

A process for producing N-methyl or N,N-dimethyl amines, which comprises using amine compound, nitro-containing compound or nitrile compound as a starting material, carbon dioxide as a methylating agent and hydrogen gas as a reducing agent, and allowing them to react in a sealed reactor for 6 to 48 h in a reaction medium at a reaction temperature of 80 to 180 ° C. in the presence of a composite catalyst, so as to provide N-methyl or N,N-dimethyl amines. The process of the present invention is simple and under relative mild reaction conditions. By means of the process of the invention, the target products can be prepared at low cost with a high yield. The catalysts used have a high catalytic activity and can be separated from the reaction system simply and reused. Furthermore, the whole process of the present invention is environmental-friendly and facilitates the cycling use of carbon dioxide.

Compounds II

The present application relates to new compounds of formula (I), to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.