206977-06-2

Upstream product

• 206977-01-7 2-(4-Methoxy-benzyl)-3-phenylsulfanyl-2,3-dihydro-isoindol-1-one 
• 206977-00-6 3-hydroxy-2-(4-methoxybenzyl)-isoindolin-1-one 
• 21244-24-6 2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione 
• 292638-85-8 acrylic acid methyl ester 
• 206977-02-8 3-Benzenesulfonyl-2-(4-methoxy-benzyl)-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

Alkylation and annulation of 3-(phenylsulfonyl)-2-alkyl-2,3- dihydroisoindol-1-ones

The hydroxylactams obtained from reduction of N-substituted phthalimides were phenylthiated and oxidized to give 3-(phenylsulfonyl)-2,3- dihydroisoindol-1-ones. Deprotonation of the sulfones with sodium hydride followed by treatment with electrophiles gave substitution. Sulfones with suitably-disposed α,β-unsaturated ester groups gave cyclic products from intramolecular Michael addition. Desulfurization of the phenylsulfonyl intermediates was effected in quantitative yield using Raney nickel promoted by ultrasound.