206977-07-3

Upstream product

• 77-78-1 dimethyl sulfate 
• 173606-49-0 2-(1-(4-methoxyphenyl)methyl)phthalimidine 
• 21244-24-6 2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione 
• 577-56-0 2-acetyl-benzoic acid 
• 2393-23-9 4-methoxy-benzylamine 
• 1542256-85-8 3-hydroxy-2-(p-methoxybenzyl)-3-methylisoindolin-1-one 
• 206977-02-8 3-Benzenesulfonyl-2-(4-methoxy-benzyl)-2,3-dihydro-isoindol-1-one 
• 206977-01-7 2-(4-Methoxy-benzyl)-3-phenylsulfanyl-2,3-dihydro-isoindol-1-one 
• 206977-00-6 3-hydroxy-2-(4-methoxybenzyl)-isoindolin-1-one 
• 206977-03-9 3-Benzenesulfonyl-2-(4-methoxy-benzyl)-3-methyl-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

LDA-induced metalation of isoindolinones. An efficient route to 3- substituted isoindoline derivatives

3-Substituted isoindolines have been efficiently prepared by sequential lithiation and reduction of isoindolinones.

Hydrogenolysis of the C-O bond of hydroxylactams as a convenient method for the synthesis of substituted isoindolin-1-ones

A simple and efficient method for the synthesis of isoindolin-1-ones containing alkyl or aryl substituents at positions 2 and (or) 3 was suggested. The method is based on the earlier unknown Pd0-catalyzed hydrogenolysis of hydroxylactams.

Novel chemoselective desulfurization of γ-phenylthio-substituted aromatic lactams: Application to the synthesis of isoindolobenzazepine alkaloid, lennoxamine

Treatment of a variety of γ-phenylthio-substituted aromatic lactams with lithium aluminum hydride in the presence of cuprous iodide led to novel chemoselective desulfurization reactions to afford the corresponding substituted aromatic lactams without givi

Alkylation and annulation of 3-(phenylsulfonyl)-2-alkyl-2,3- dihydroisoindol-1-ones

The hydroxylactams obtained from reduction of N-substituted phthalimides were phenylthiated and oxidized to give 3-(phenylsulfonyl)-2,3- dihydroisoindol-1-ones. Deprotonation of the sulfones with sodium hydride followed by treatment with electrophiles gave substitution. Sulfones with suitably-disposed α,β-unsaturated ester groups gave cyclic products from intramolecular Michael addition. Desulfurization of the phenylsulfonyl intermediates was effected in quantitative yield using Raney nickel promoted by ultrasound.