206990-79-6Relevant articles and documents
A new synthetic approach to a fungal β-lactone based on the asymmetric [2,3]-wittig rearrangement
Tomooka, Katsuhiko,Takeda, Takahiro,Kuen, Au Wing,Nakai, Takeshi
, p. 671 - 674 (2007/10/03)
An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2' and C