206999-33-9

Basic information

• Product Name: 2-(4-chlorophenoxy)-N-(2-hydroxy-5-methylphenyl)acetamide
• Synonyms: 2-(4-chlorophenoxy)-N-(2-hydroxy-5-methylphenyl)acetamide
• CAS NO: 206999-33-9
• Molecular Formula: C15H14ClNO3
• Molecular Weight: 291.72956
• Mol File: 206999-33-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-chlorophenoxy)-N-(2-hydroxy-5-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenoxy)-N-(2-hydroxy-5-methylphenyl)acetamide(206999-33-9)
• EPA Substance Registry System: 2-(4-chlorophenoxy)-N-(2-hydroxy-5-methylphenyl)acetamide(206999-33-9)

Safety Data

• Hazardous Substances Data: 206999-33-9(Hazardous Substances Data)

Upstream product

• 122-88-3 4-Chlorophenoxyacetic acid 
• 95-84-1 3-amino-4-hydroxytoluene 
• 4122-68-3 4-chlorophenyloxyacetyl chloride 

Relevant articles and documents

Synthesis and microbiological activity of some novel N-(2-hydroxyl-5- substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides as the possible metabolites of antimicrobial active benzoxazoles

Synthesis of some novel N-(2-hydroxyl-5- substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides (5a-k) were described in order to determine their in vitro antimicrobial activity against 3 Gram-positive, 3 Gram-negative bacteria and the fungus Candida albicans comparing with several control drugs. The derivative 5e was found active at a MIC value of 25μg/ml against the whole tested Gram- positive bacteria strains and the Gram-negative microorganism Klebsiella pneumoniae. Moreover, the synthesized compounds 5a-k exhibited significant antibacterial activity against the enterobacter Pseudomonas aureginosae when compared to the control drugs. For the antifungal activity against C. albicans, the compound 5k was found more active than the other synthesized derivatives. On the other hand, the antimicrobial activity of some of these acetamide derivatives (5c, 5d, 5e, 5j and 5k) which are the possible metabolites of benzoxazoles, were also compared with their cyclic analogues 6-10. However, most of the MIC values of the benzoaxazole derivatives provided better activity than the compared acetamides, while some others of the acetamide derivatives possessed either one fold improved (5d, 5e and 5j) or the same potency (5c, 5d, 5e, 5j and 5k) against the tested microorganisms.